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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
9
hits in this display
Target
Cholinesterase
(Homo sapiens (Human))
Sichuan University
Curated by
ChEMBL
Ligand
BDBM50240945
((E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(...)
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Affinity Data
Ki: 3.48E+3nM
Assay Description:
Mixed type inhibition of BChE (unknown origin) using butyrylthiocholine iodide as substrate by Ellman's method based Lineweaver-Burk plot analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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Target
Acetylcholinesterase
(Homo sapiens (Human))
Sichuan University
Curated by
ChEMBL
Ligand
BDBM50240945
((E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(...)
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Affinity Data
Ki: 7.39E+3nM
Assay Description:
Competitive type inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate by Ellman's method based Lineweaver-Burk plot analys...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Cholinesterase
(Homo sapiens (Human))
Sichuan University
Curated by
ChEMBL
Ligand
BDBM50240945
((E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(...)
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Affinity Data
IC50: 2.57E+3nM
Assay Description:
Binding affinity to BChE (unknown origin) assessed as reduction in intrinsic protein fluorescence at 25 degC by fluorescence spectrophotometry
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Ornithine decarboxylase
(Homo sapiens (Human))
University Of California
Curated by
ChEMBL
Ligand
BDBM50240945
((E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(...)
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Affinity Data
IC50: 4.70E+3nM
Assay Description:
Inhibition of phorbol ester-induced ornithine decraboxylase in human MCF7 cells after 6 hrs
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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In Depth
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Article
PubMed
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Target
Cholinesterase
(Homo sapiens (Human))
Sichuan University
Curated by
ChEMBL
Ligand
BDBM50240945
((E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(...)
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Affinity Data
IC50: 5.68E+3nM
Assay Description:
Inhibition of BChE (unknown origin) using butyrylthiocholine iodide as substrate by spectrophotometry based Ellman's method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Beta-secretase 1
(Homo sapiens (Human))
Sichuan University
Curated by
ChEMBL
Ligand
BDBM50240945
((E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(...)
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Affinity Data
IC50: 9.80E+3nM
Assay Description:
Inhibition of BACE1 (unknown origin) expressed in baculovirus-expression system using Rh-EVNLDAEFK-Quencher substrate by FRET assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
PC cid
PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Acetylcholinesterase
(Homo sapiens (Human))
Sichuan University
Curated by
ChEMBL
Ligand
BDBM50240945
((E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(...)
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Affinity Data
IC50: 1.71E+4nM
Assay Description:
Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate by spectrophotometry based Ellman's method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Acetylcholinesterase
(Homo sapiens (Human))
Sichuan University
Curated by
ChEMBL
Ligand
BDBM50240945
((E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.96E+4nM
Assay Description:
Binding affinity to AChE (unknown origin) assessed as reduction in intrinsic protein fluorescence at 25 degC by fluorescence spectrophotometry
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Toho University
Curated by
ChEMBL
Ligand
BDBM50240945
((E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(...)
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Affinity Data
IC50: 7.41E+4nM
Assay Description:
Inhibition of PTP1B (unknown origin) using p-nitrophenyl phosphate as substrate
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI