Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 17 hits in this display
ADAMTS5(Rattus norvegicus (Rat))Galapagos
US Patent
BDBM379622(US9926281, Compound 135)
BDBM379622(US9926281, Compound 135)
BDBM379622(US9926281, Compound 135)
IC50: 178nMAssay Description:Inhibition of human recombinant ADAMTS-5 assessed as cleavage of fluorescent substrate using FAM-TBIS-1 by biochemical assayMore data for this Ligand-Target Pair
ADAMTS5(Rattus norvegicus (Rat))Galapagos
US Patent
BDBM379609(US9926281, Compound 106)
IC50: 222nMAssay Description:ADAMTS-4:The basis for the assay is the cleavage of the substrate TBIS-1 (5-FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMTS4For the do...More data for this Ligand-Target Pair
BDBM379622(US9926281, Compound 135)
BDBM379609(US9926281, Compound 106)
IC50: 233nMAssay Description:ADAMTS-5:Protocol 1: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...More data for this Ligand-Target Pair
BDBM379622(US9926281, Compound 135)
BDBM379739(US9926281, Compound 128)
IC50: 1.17E+3nMAssay Description:ADAMTS-5:Protocol 1: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...More data for this Ligand-Target Pair
BDBM379739(US9926281, Compound 128)
IC50: 1.17E+3nMAssay Description:Inhibition of human recombinant ADAMTS-5 assessed as cleavage of fluorescent substrate using FAM-TBIS-1 by biochemical assayMore data for this Ligand-Target Pair
BDBM379739(US9926281, Compound 128)
IC50: 1.95E+3nMAssay Description:MMP2: Protocol 2: The basis for the assay is the cleavage of the substrate 390 MMP FRET substrate I (Anaspec, Catalog n#: AS-27076) by human MMP2 (R&...More data for this Ligand-Target Pair
BDBM379739(US9926281, Compound 128)
BDBM379609(US9926281, Compound 106)
IC50: >2.00E+4nMAssay Description:MMP2: Protocol 2: The basis for the assay is the cleavage of the substrate 390 MMP FRET substrate I (Anaspec, Catalog n#: AS-27076) by human MMP2 (R&...More data for this Ligand-Target Pair
BDBM379739(US9926281, Compound 128)
BDBM379622(US9926281, Compound 135)
IC50: >2.00E+4nMAssay Description:MMP-13:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat # AS-27076) by human MMP13 (Chemicon, Cat #CC06...More data for this Ligand-Target Pair
BDBM379609(US9926281, Compound 106)
IC50: >2.00E+4nMAssay Description:MMP-13:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat # AS-27076) by human MMP13 (Chemicon, Cat #CC06...More data for this Ligand-Target Pair
BDBM379609(US9926281, Compound 106)
IC50: >2.00E+4nMAssay Description:TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...More data for this Ligand-Target Pair
BDBM379622(US9926281, Compound 135)
IC50: >2.00E+4nMAssay Description:TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...More data for this Ligand-Target Pair