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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
48
hits in this display
Target
Mu-type opioid receptor
(Homo sapiens (Human))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
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Affinity Data
Ki: 0.600nM
More data for this Ligand-Target Pair
Target Info
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Target
Mu-type opioid receptor
(Homo sapiens (Human))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.720nM
More data for this Ligand-Target Pair
Target Info
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Target
Mu-type opioid receptor
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.945nM
More data for this Ligand-Target Pair
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Target
Mu-type opioid receptor
(GUINEA PIG)
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.40nM
More data for this Ligand-Target Pair
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Target
Mu-type opioid receptor
(Homo sapiens (Human))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.45nM
More data for this Ligand-Target Pair
Target Info
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Target
Mu-type opioid receptor
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.70nM
More data for this Ligand-Target Pair
Target Info
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Target
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50223633
(Levomethadone)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2nM
Assay Description:
Inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the absence of Na
More data for this Ligand-Target Pair
Target Info
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Target
Mu-type opioid receptor
(Homo sapiens (Human))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 5.60nM
More data for this Ligand-Target Pair
Target Info
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Target
Mu-type opioid receptor
(Homo sapiens (Human))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 13nM
Assay Description:
Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK293 cell membrane incubated for 60 mins by radioligand binding assay
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
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Affinity Data
Ki: 14.1nM
More data for this Ligand-Target Pair
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Target
Kappa-type opioid receptor
(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
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Affinity Data
Ki: 15.8nM
More data for this Ligand-Target Pair
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Target
Mu-type opioid receptor
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 19nM
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Mu-type opioid receptor
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 19.7nM
More data for this Ligand-Target Pair
Target Info
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Target
Aldehyde oxidase 1
(Rattus norvegicus)
Pfizer
Curated by
ChEMBL
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
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Affinity Data
Ki: 30nM
Assay Description:
Inhibition of rat aldehyde oxidase
More data for this Ligand-Target Pair
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Target
Delta-type opioid receptor
(GUINEA PIG)
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
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Affinity Data
Ki: 37.3nM
More data for this Ligand-Target Pair
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Target
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50223633
(Levomethadone)
Copy SMILES
Copy InChI
Affinity Data
Ki: 77nM
Assay Description:
Compound was evaluated for the inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the presence of Na
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
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KEGG
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Target
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50223640
((S)-Methadone | CHEMBL350719)
Copy SMILES
Copy InChI
Affinity Data
Ki: 110nM
Assay Description:
Inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the absence of Na
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
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CHEMBL
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Article
PubMed
Copy BDB DOI
Target
Delta-type opioid receptor
(Homo sapiens (Human))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 132nM
More data for this Ligand-Target Pair
Target Info
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Reactome pathway
KEGG
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antibodypedia
GoogleScholar
Ligand Info
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ChEBI
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Copy BDB DOI
Target
Kappa-type opioid receptor
(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 324nM
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
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antibodypedia
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Ligand Info
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ChEBI
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PubMed
Copy BDB DOI
Target
Delta-type opioid receptor
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 371nM
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
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Ligand Info
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ChEBI
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KEGG
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In Depth
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PubMed
Copy BDB DOI
Target
Kappa-type opioid receptor
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 405nM
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
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Ligand Info
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ChEBI
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In Depth
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PubMed
Copy BDB DOI
Target
Delta-type opioid receptor
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 435nM
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Norepinephrine transporter
(RAT)
R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 702nM
More data for this Ligand-Target Pair
Target Info
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Target
Kappa-type opioid receptor
(Cavia porcellus (domestic guinea pig))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 728nM
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Delta-type opioid receptor
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 960nM
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
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ChEBI
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 992nM
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Kappa-type opioid receptor
(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.00E+3nM
More data for this Ligand-Target Pair
Target Info
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KEGG
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antibodypedia
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ChEBI
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PubMed
Copy BDB DOI
Target
Delta-type opioid receptor
(Homo sapiens (Human))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.00E+3nM
More data for this Ligand-Target Pair
Target Info
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Reactome pathway
KEGG
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antibodypedia
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ChEBI
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Copy BDB DOI
Target
Delta-type opioid receptor
(Homo sapiens (Human))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.00E+3nM
More data for this Ligand-Target Pair
Target Info
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Reactome pathway
KEGG
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antibodypedia
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Copy BDB DOI
Target
Kappa-type opioid receptor
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.37E+3nM
More data for this Ligand-Target Pair
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Target
Kappa-type opioid receptor
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.86E+3nM
More data for this Ligand-Target Pair
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Target
D(3) dopamine receptor
(Homo sapiens)
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
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Affinity Data
Ki: 2.11E+3nM
Assay Description:
Displacement of [3H]-N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cell membranes incubated for 60 mins by microbeta scintill...
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Target
D(2) dopamine receptor
(BOVINE)
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
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Affinity Data
Ki: 2.70E+3nM
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Target
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50223640
((S)-Methadone | CHEMBL350719)
Copy SMILES
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Affinity Data
Ki: 3.20E+3nM
Assay Description:
Compound was evaluated for the inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the presence of Na
More data for this Ligand-Target Pair
Target Info
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MMDB
Reactome pathway
KEGG
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Target
Cytochrome P450 2B6
(Homo sapiens (Human))
University Of Michigan
Curated by
ChEMBL
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
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Affinity Data
Ki: 1.00E+4nM
Assay Description:
Inactivation of C-terminal His4-tagged human CYP2B6 lacking 21 N-terminal residues expressed in Escherichia coli C41 (DE3) assessed as decreases in f...
More data for this Ligand-Target Pair
Target Info
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Target
D(1A) dopamine receptor
(BOVINE)
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
Copy SMILES
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Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
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Norepinephrine transporter
(RAT)
R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
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Affinity Data
Ki: >1.00E+4nM
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D(4) dopamine receptor
(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
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Affinity Data
Ki: 2.62E+4nM
Assay Description:
Displacement of [3H]-N-methylspiperone from human dopamine D4 receptor expressed in HEK293 cell membranes incubated for 60 mins by microbeta scintill...
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D(2) dopamine receptor
(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
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Ki: >1.00E+5nM
Assay Description:
Displacement of [3H]-N-methylspiperone from human dopamine D2 receptor expressed in HEK293 cell membranes incubated for 60 mins by microbeta scintill...
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Mu-type opioid receptor
(Homo sapiens (Human))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
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IC50: 4.10nM
Assay Description:
Binding affinity against mu-opiate receptor (human) using [3H]DAMGO radioligand
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NCI pathway
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Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
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IC50: 51nM
Assay Description:
Displacement of [3H]naloxone from Sprague-Dawley rat cerebellum opioid receptor assessed as relative receptor affinity by scintillation counting
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Target
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
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Affinity Data
IC50: 51nM
Assay Description:
Displacement of [3H]naloxone from Sprague-Dawley rat cerebellum opioid receptor assessed as relative receptor affinity by scintillation counting
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Kappa-type opioid receptor
(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
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IC50: 512nM
Assay Description:
Binding affinity against opioid receptor kappa 1 using [3H]- U-69,593 radioligand
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Delta-type opioid receptor
(Homo sapiens (Human))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
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Affinity Data
IC50: 1.09E+3nM
Assay Description:
Binding affinity against delta-opiate receptor (human) using [3H]-DPDPE radioligand
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ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Tufts University School Of Medicine
Curated by
ChEMBL
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
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IC50: 7.50E+3nM
Assay Description:
TP_TRANSPORTER: inhibition of Rhodamine 123 transepithelial transport (basal to apical) (Rhodamine 123: 5 uM) in Caco-2 cells
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Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Reverse Proteomics Research Institute
Curated by
ChEMBL
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
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IC50: 9.77E+3nM
Assay Description:
Inhibitory concentration against potassium channel HERG
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Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S
(Homo sapiens (Human))
Chantest
Curated by
ChEMBL
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
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IC50: 3.74E+4nM
Assay Description:
Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits
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Mas-related G-protein coupled receptor member X2
(Homo sapiens (Human))
University of North Carolina
Ligand
BDBM82507
((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)
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EC50: 4.40E+4nM
pH: 7.4 T: 2°C
Assay Description:
HTLA cells (HEK-T cells stably expressing a β-arrestin2-TEV fusion protein and a tTa-dependent luciferase reporter) were maintained in DMEM (Cor...
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