Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 17 hits in this display   

TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50:  2.70nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50:  2.70nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50:  4.36nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50:  4.36nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50:  4.36nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetTyrosine-protein kinase BTK [C481S](Homo sapiens (Human))
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50:  14.1nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetTyrosine-protein kinase BTK [C481S](Homo sapiens (Human))
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50:  14.1nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetTyrosine-protein kinase BTK [C481S](Homo sapiens (Human))
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50:  14.1nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetFocal adhesion kinase 1(Homo sapiens (Human))
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50:  24.6nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetFocal adhesion kinase 1(Homo sapiens (Human))
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50:  24.6nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetFocal adhesion kinase 1(Homo sapiens (Human))
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50:  24.6nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50:  447nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50:  447nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50:  714nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+3nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+3nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+3nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI