Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 90 hits in this display   

TargetCannabinoid receptor 1(Homo sapiens (Human))
Universita Del Piemonte Orientale

LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  11nM ΔG°:  -46.2kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Saint Louis University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]CP-55,940 binding to Cannabinoid receptor 1 in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1/2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  25nMAssay Description:Binding affinity towards cannabinoid receptor using [3H]CP-55940 as radioligand in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCB1 cannabinoid receptor-interacting protein 1(theromyzon Tessulatum)
State University of New York At Old Westbury

Curated by PDSP Ki Database
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  33.3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Hirudo medicinalis)
State University of New York At Old Westbury

Curated by PDSP Ki Database
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  35.8nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Saint Louis University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  39nMAssay Description:In vitro binding affinity was determined against rat brain Cannabinoid receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Universita Del Piemonte Orientale

LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  39.2nMAssay Description:Compound was evaluated for its binding affinity towards Cannabinoid receptor 1 [Inactive form(R) of CB1 receptor]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Universita Del Piemonte Orientale

LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  50nMAssay Description:Binding affinity to CB1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Universita Del Piemonte Orientale

LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  50nMAssay Description:Binding affinity for human cannabinoid receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1/2(MOUSE)
Hebrew University

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  52nMAssay Description:Ability to displace [3H]HU-243 binding to cannabinoid receptor in synaptosomal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Saint Louis University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  61nMAssay Description:Binding affinity towards cannabinoid receptor 1 from rat forebrain membranes in the presence of phenylmethanesulfonylfluoride (PMSF) using 0.8 nM [3H...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Universita Del Piemonte Orientale

LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  70nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in human HEK293 cells in presence of 100 nM PMSFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Universita Del Piemonte Orientale

LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  70nMAssay Description:Binding affinity to human recombinant CB1 receptor expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Universita Del Piemonte Orientale

LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  70nMAssay Description:Displacement of [3H]CP55-940 from human recombinant CB1 receptor expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Universita Del Piemonte Orientale

LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  70nMAssay Description:Displacement of [3H]CP55-940 from human recombinant CB1 receptor in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Universita Del Piemonte Orientale

LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  72nMAssay Description:Displacement of [3H]CP-55,940 from human recombinant CB1 receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Universita Del Piemonte Orientale

LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  72nMAssay Description:Binding affinity to human recombinant CB1 receptor expressed in african green monkey COS cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Universita Del Piemonte Orientale

LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  72nMAssay Description:Displacement of [3H]CP-55940 from human recombinant CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Saint Louis University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  72nMAssay Description:Binding affinity for cannabinoid receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Universita Del Piemonte Orientale

LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  72nMAssay Description:Displacement of [3H]CP-55940 from human CB1 receptor expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Universita Del Piemonte Orientale

LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  72nMAssay Description:Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Universita Del Piemonte Orientale

LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  72nMAssay Description:Displacement of [3H]-CP55940 from human recombinant CB1 receptor expressed in HEK cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Saint Louis University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  74nMAssay Description:Displacement of [3H]CP-55,940 from CB1 receptor in rat brain membranes in presence of FAAH inhibitor PMSF by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1/2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  78nMAssay Description:Binding affinity for the cannabinoid receptor in the presence of phenylmethanesulfonyl fluoride (PMSF) was determined in rat fore brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Saint Louis University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  78nMAssay Description:Displacement of [3H]-CP-55,940 from Cannabinoid receptor 1 of rat forebrain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Saint Louis University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  78nMAssay Description:Tested for binding affinity to Cannabinoid receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Saint Louis University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  89nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Universita Del Piemonte Orientale

LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  89nMAssay Description:Binding affinity towards cloned human Cannabinoid receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Universita Del Piemonte Orientale

LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  89nMAssay Description:Binding affinity to CB1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Saint Louis University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  89nMAssay Description:Displacement of [3H]CP55940 from CB1 receptor in Wistar rat brain incubated for 60 mins by radioactive filter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
Organix

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  89nMAssay Description:Binding affinity for Cannabinoid receptor 1 in presence of phenylmethylsulfonyl fluoride (PMSF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Universita Del Piemonte Orientale

LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  89nMAssay Description:Binding affinity to human CB1 receptor in presence of serine protease inhibitor PMSFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Saint Louis University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  89nMAssay Description:The compound was tested for Ki value against rat whole brain P2 membrane preparation in presence of enzyme inhibitor PMSF.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Saint Louis University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  90nMAssay Description:Displacement of [3H]-CP-55,940 from rat forebrain membrane which expresses Cannabinoid receptor 1 in the presence of PMSFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Saint Louis University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  90nMAssay Description:Binding affinity of the compound towards Cannabinoid receptor 1 in rat forebrain membranes using [3H]-CP-55,940 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid-binding protein, liver(Mus musculus (Mouse))
Avanti Polar Lipids

LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  111nMAssay Description:The following fluorescent ligand displacement assays at 24 °C were used to further confirm and/or determine if the cytosolic lipidic ligand "chaperon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Saint Louis University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  132nMAssay Description:Displacement of [3H]SR141716A from CB1 receptor in rat cerebellar membrane after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  160nMAssay Description:Displacement of [3H]CP-55,940 from human CB2 receptor expressed in HEK293 cell membranes in absence of FAAH inhibitor PMSF by radioligand binding ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  168nM ΔG°:  -39.3kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  169nMAssay Description:Binding affinity to vanilloid VR1 receptor using [3H]resiniferatoxin ([3H]-RTX) in rat spinal cord membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]CP-55940 from human recombinant CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]CP55-940 from human recombinant CB2 receptor expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]CP55-940 from human recombinant CB2 receptor in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  180nMAssay Description:Binding affinity to human recombinant CB2 receptor expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1/2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  282nMAssay Description:Binding affinity towards cannabinoid receptor using [3H]SR-141,716A as radioligand in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Saint Louis University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  285nMAssay Description:Binding affinity to CB1 cannabinoid receptor using [3H]WIN-55212-2 in rat cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Universita Del Piemonte Orientale

LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  300nMAssay Description:Ability of the compound to displace [3H]-CP-55,940 from the membranes prepared from HEK cell line with W6 48(357)A mutant in Cannabinoid receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Universita Del Piemonte Orientale

LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  300nMAssay Description:Ability of the compound to displace [3H]-CP-55,940 from the membranes prepared from HEK cell line with W5 43(280)A mutant Cannabinoid receptor 1 at 5...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Universita Del Piemonte Orientale

LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  300nMAssay Description:Ability of the compound to displace [3H]-CP-55,940 from the membranes prepared from HEK cell line with F3.36 (201)A mutant Cannabinoid receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Universita Del Piemonte Orientale

LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  300nMAssay Description:Ability of the compound to displace [3H]-CP-55,940 from the membranes prepared from HEK cell line with wild type Cannabinoid receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  306nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCannabinoid receptor 2(Rattus norvegicus (Rat))
Utrecht University

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  360nMAssay Description:Displacement of [3H]-CP-55,940 from rat forebrain membrane which expresses Cannabinoid receptor 2 in the presence of PMSFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  370nMAssay Description:Binding affinity towards cloned human cannabinoid receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  371nMAssay Description:Binding affinity to CB2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  371nMAssay Description:Binding affinity to human CB2 receptor in presence of serine protease inhibitor PMSFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Saint Louis University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  400nMAssay Description:Displacement of [3H]SR141716A from CB1 receptor in CD rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Saint Louis University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  800nMAssay Description:Concentration required to displace 0.4 nM [3H]-SR-141,716A from CB1 receptor in rat brain preparations in the presence of 0.1 mM phenylmethyl sulphon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Saint Louis University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]CP-55,940 from CB1 receptor in rat brain membranes in absence of FAAH inhibitor PMSF by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(MOUSE)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]CP-55,940 from mouse CB2 receptor expressed in HEK293 cell membranes in absence of FAAH inhibitor PMSF by radioligand binding ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to human CB2 cannabinoid receptor using [3H]CP-55940 in HEK293 EBNA transfected cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1/2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi: >1.18E+3nMAssay Description:Binding affinity for the cannabinoid receptor in the absence of phenylmethanesulfonyl fluoride (PMSF) was determined in rat fore brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(MOUSE)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  1.48E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Universita Del Piemonte Orientale

LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  1.80E+3nMAssay Description:Ability of the compound to displace [3H]-CP-55,940 from the membranes prepared from HEK cell line with F3.25 (190)A mutant Cannabinoid receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(MOUSE)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  1.93E+3nMAssay Description:Compound was evaluated for its binding affinity for mouse spleen Cannabinoid receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(MOUSE)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  1.93E+3nMAssay Description:Binding affinity towards Cannabinoid receptor 2 from mouse spleen membranes using 0.8 nM [3H]-CP-55,940 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Umr Cnrs 5074

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  3.00E+3nMAssay Description:Binding affinity of the compound towards Fatty-acid amide hydrolase (FAAH) in rat forebrain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
Organix

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  5.40E+3nMAssay Description:Binding affinity for Cannabinoid receptor 1 in absence of phenylmethylsulfonyl fluoride (PMSF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Saint Louis University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  5.40E+3nMAssay Description:The compound was tested for Ki value against rat whole brain P2 membrane preparation in absence of enzyme inhibitor PMSFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Saint Louis University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi:  5.81E+3nMAssay Description:Binding affinity towards cannabinoid receptor 1 from rat forebrain membranes in the absence of phenylmethanesulfonylfluoride (PMSF) using 0.8 nM [3H]...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Utrecht University

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of Fatty-acid amide hydrolase (FAAH) activity in human lymphoma U937 cell using [3H]-AEA as substrate in the 0-25 uM concMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Rattus norvegicus (Rat))
Utrecht University

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
Organix

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataIC50:  39nMAssay Description:Binding affinity towards Cannabinoid receptor 1 was determined using [3H]-CP- cannabinoid as radioligand with mouse brain memebrane in the presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Saint Louis University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataIC50:  40nMAssay Description:Binding affinity towards Cannabinoid receptor 1 was determined using [3H]-CP- cannabinoid as radioligand with rat brain memebrane in the presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 2(Rattus norvegicus)
National Research Council (Cnr)

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataIC50:  960nMAssay Description:Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium two pore domain channel subfamily K member 2(Bos taurus)
Universit£

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Activation of bovine TREK1 expressed in AZT cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium channel subfamily K member 3(Homo sapiens (Human))
Universidad De Talca

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human TASK1 expressed in African green monkey COS7 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Utrecht University

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of FAAHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Utrecht University

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of FAAH (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 2(Rattus norvegicus)
National Research Council (Cnr)

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataIC50:  8.60E+3nMAssay Description:Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Umr Cnrs 5074

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataIC50:  1.17E+4nMAssay Description:Inhibition of rat recombinant FAAH-mediated hydrolysis of [3H]AEAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
Organix

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataIC50:  1.20E+4nMAssay Description:Binding affinity towards Cannabinoid receptor 1 was determined using [3H]-CP- cannabinoid as radioligand with mouse brain memebraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol 14-alpha demethylase(Homo sapiens (Human))
Act

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human CYP51 expressed in Topp 3 cells by lanosterol demethylase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Saint Louis University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataEC50:  1.58E+4nMAssay Description:Displacement of [35S]GTP-gamma-S from rat cerebellar CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Saint Louis University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataEC50:  69nMAssay Description:Agonist activity at rat CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Saint Louis University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataEC50:  1.58E+4nMAssay Description:Cannabinoid receptor 1 dependent activity of compound was evaluated by using [35S]GTP-gamma-S-binding studiesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataEC50:  16nMAssay Description:Agonist activity at TRPV1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataEC50:  490nMAssay Description:Agonist activity on human recombinant TRPV1-mediated enhancement of intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataEC50:  630nMAssay Description:Activation of human VR1 expressed in HEK293 cells assessed as stimulation of Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataEC50:  200nMAssay Description:The effect of the substances on Ca2+ influx was determined by using HEK-293 cells stably overexpressing recombinant human TRPV1 cDNA. The cells were ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid-binding protein 5-ANS(Mus musculus (Mouse))
Case Western Reserve University School of Medicine

LigandPNGBDBM22988((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Affinity DataKd:  100nMAssay Description:The method entails two steps [Lin et al., Biochemistry, 38:185-190]. In the first step, the Kd for association of FABP5 with the fluorescent lipid pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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