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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 17 hits in this display   

LigandPNGBDBM7377(4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | ...)
Affinity DataIC50:  150nMAssay Description:Inhibition of CDK1/cyclinBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Faculte De Medecine Et De Pharmacie

LigandPNGBDBM7377(4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | ...)
Affinity DataIC50:  150nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM7377(4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | ...)
Affinity DataIC50:  150nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Faculte De Medecine Et De Pharmacie

LigandPNGBDBM7377(4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | ...)
Affinity DataIC50:  200nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM7377(4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | ...)
Affinity DataIC50:  200nMAssay Description:Inhibition of CDK5/p25 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM7377(4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | ...)
Affinity DataIC50:  200nMAssay Description:Inhibition of cyclin-dependent kinase 5/p25; range 0.16-0.2More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Cnrs Usr-3151

Curated by ChEMBL
LigandPNGBDBM7377(4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | ...)
Affinity DataIC50:  200nMAssay Description:Inhibition of GST-fused recombinant CDK5/p25 expressed in Escherichia coli after 30 mins by scintillation countingMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM7377(4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | ...)
Affinity DataIC50:  646nMAssay Description:Inhibitory concentration against Glycogen synthase kinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM7377(4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | ...)
Affinity DataIC50:  650nMAssay Description:Inhibition of GSK3alpha/beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Faculte De Medecine Et De Pharmacie

LigandPNGBDBM7377(4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | ...)
Affinity DataIC50:  650nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM7377(4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | ...)
Affinity DataIC50:  650nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM7377(4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | ...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of GSK3alphaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM7377(4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | ...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of GSK3-betaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Saccharomyces cerevisiae)
Cnrs Usr-3151

Curated by ChEMBL
LigandPNGBDBM7377(4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | ...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of hemagglutinin-tagged Saccharomyces cerevisiae MNY629 Cdc28/Clb2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM7377(4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | ...)
Affinity DataEC50:  150nMAssay Description:Activity at human wild type CFTR expressed in CHO cells assessed as forskolin stimulated iodide fluxChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM7377(4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | ...)
Affinity DataEC50:  140nMAssay Description:Activity at human wild type CFTR expressed in Calu3 cells assessed as forskolin stimulated iodide fluxChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM7377(4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | ...)
Affinity DataEC50:  111nMAssay Description:Activity at human wild type CFTR expressed in F508del-CF1 cells assessed as forskolin stimulated iodide fluxChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed