Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 104 hits in this display
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Ki: 0.870nMAssay Description:Binding affinity of compound measured using [3H]-spiperone for the cloned human dopamine receptor D2 long (high/low affinity is given as 9.0/1800)More data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Ki: 0.880nMAssay Description:High binding affinity towards human dopamine receptor 3 expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligandMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Ki: 0.900nMAssay Description:Displacement of [3H]-N-methylspiperone from D3 receptor (unknown origin) measured after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Ki: 0.940nMAssay Description:Displacement of [3H]-7-OH-DPAT from human D3R expressed in HEK293 cell membranes measured after 90 mins in Tris buffer by topcount assayMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Ki: 1.10nMAssay Description:Displacement of [3H]-7-OH-DPAT from human D3R expressed in HEK293 cell membranes measured after 90 mins in EBSS buffer by topcount assayMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Ki: 4.70nMAssay Description:Displacement of [3H]-methylspiperon from human D2RL expressed in HEK293 cell membranes measured after 90 mins by topcount assayMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Ki: 8.10nMAssay Description:High binding affinity towards human dopamine receptor 4.4 expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligandMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Ki: 8.20nMAssay Description:Displacement of [3H]-methylspiperon from human D3R expressed in HEK293 cell membranes measured after 90 mins in EBSS buffer by topcount assayMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Ki: 8.5nMAssay Description:Binding affinity of compound measured using [3H]-spiperone for the cloned human Dopamine receptor D3 (high/low affinity is given as 25/1600)More data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Ki: 13nMAssay Description:Displacement of [3H]-methylspiperon from human D3R expressed in HEK293 cell membranes measured after 90 mins in Tris buffer by topcount assayMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Ki: 21nMAssay Description:High binding affinity towards human dopamine receptor 2 (long) expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligandMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Ki: 21nMAssay Description:High binding affinity towards human dopamine receptor 2 (short) expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligandMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Ki: 27nMAssay Description:Binding affinity of compound measured using [3H]-spiperone for the cloned human dopamine receptor D2 long (high/low affinity is given as 27/5400)More data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Ki: 38nMAssay Description:Low binding affinity towards human dopamine receptor 3 expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligandMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Ki: 40nMAssay Description:Binding affinity of compound measured using [3H]-spiperone for the cloned human dopamine receptor D4.4 (high/low affinity is given as 8.5/130)More data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Ki: 130nMAssay Description:Low binding affinity towards human dopamine receptor 4.4 expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligandMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Ki: 1.90E+3nMAssay Description:Low binding affinity towards human dopamine receptor 2 (short) expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligandMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Ki: 4.45E+3nMAssay Description:Displacement of [3H]-pentazocine from sigma1 receptor (unknown origin) after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Ki: 6.30E+3nMAssay Description:Low binding affinity towards human dopamine receptor 2 (long) expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligandMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Ki: >1.00E+4nMAssay Description:Displacement of [3H]-prazosin from recombinant human alpha1A adrenergic receptor measured after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
IC50: 4.70E+3nMAssay Description:Affinity of the Compound for Dopamine receptor D2 in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]spiperone as ligandMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Kd: 1.60nMAssay Description:Binding affinity of compound against Dopamine receptor D2 was measured using [3H]-pramipexole in Bovine striatal membranesMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
EC50: 12nMAssay Description:Effective concentration to stimulate rat Dopamine receptor D2S mediated [3H]-thymidine incorporation into growing cells using mitogenesis assayMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
EC50: 9.20nMAssay Description:Effective concentration to stimulate rat Dopamine receptor D2L mediated [3H]-thymidine incorporation into growing cells using mitogenesis assayMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
EC50: 15nMAssay Description:Effective concentration to stimulate human Dopamine receptor D4.2 mediated [3H]-thymidine incorporation into growing cells using mitogenesis assayMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
EC50: 1.5nMAssay Description:Effective concentration to stimulate human Dopamine receptor D3 mediated [3H]-thymidine incorporation into growing cells using mitogenesis assayMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
EC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
EC50: 5nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
EC50: 12nMAssay Description:Binding affinity of compound measured using [3H]-spiperone for the cloned human dopamine receptor D2 long (high/low affinity is given as 230/53000)More data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Kd: 12nMAssay Description:Displacement of [3H]UR-DE257 from human histamine H2 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RG-Salpha S in...More data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Kd: 0.0149nMAssay Description:Displacement of [3H]N-methylspiperone from human D2 long receptor stably expressed in HEK293T cells co-expressing luciferase and CEK at high concentr...More data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Kd: 0.0258nMAssay Description:Displacement of [3H]N-methylspiperone from human D3 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 140 min...More data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
EC50: 0.813nMAssay Description:Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
EC50: 251nMAssay Description:Agonist activity at human D2 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding by Perkin elmer analysisMore data for this Ligand-Target Pair
BDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
EC50: 4.10nMAssay Description:Agonist activity at human D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding by Perkin elmer analysisMore data for this Ligand-Target Pair
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