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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
25
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Target
ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
Ki: 4.20E+3nM
Assay Description:
Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affini...
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Target
ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
IC50: 331nM
Assay Description:
Inhibition of P-glycoprotein-mediated daunorubicin efflux from human CCRF-CEM/VCR1000 cells after 240 secs by FACS flow cytometric analysis
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
IC50: 440nM
Assay Description:
Inhibition of hERG K channel
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
IC50: 800nM
Assay Description:
Inhibitory concentration against IKr potassium channel
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Target
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
IC50: 1.19E+3nM
Assay Description:
Inhibition of sodium current measured using whole-cell patch clamp experiments in HEK-293 cells stably transfected with hNaV1.5 cDNA
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Target
Voltage-dependent L-type calcium channel subunit alpha-1C
(Cavia porcellus)
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
IC50: 1.80E+3nM
Assay Description:
Inhibition of calcium current (ICaL) measured using whole-cell patch clamp experiments in isolated guinea pig ventricular myocytes
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Target
Voltage-dependent L-type calcium channel subunit alpha-1C
(Cavia porcellus)
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
IC50: 1.80E+3nM
Assay Description:
Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes
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Target
ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
IC50: 2.20E+3nM
Assay Description:
Inhibition of human kir6.2/SUR2A ion channel coexpressed in human HEK293 cells after 5 mins by patch clamp assay
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Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
IC50: 2.88E+3nM
Assay Description:
Inhibition of human cloned ERG channel expressed in chinese hamster CHO cells after 5 mins by patch clamp assay
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Target
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
IC50: 3.30E+3nM
Assay Description:
Inhibition of human cloned Nav1.5 channel expressed in chinese hamster CHO cells assessed as tonic inhibition after 5 mins by patch clamp assay
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Target
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
IC50: >5.00E+3nM
Assay Description:
Inhibition of human cloned Nav1.5 channel expressed in chinese hamster CHO cells assessed as phasic inhibition after 5 mins by patch clamp assay
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Potassium channel subfamily K member 3
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
IC50: 5.10E+3nM
Assay Description:
Inhibition of of TASK1 (unknown origin) expressed in CHO cells assessed as reduction in channel currents
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Target
Potassium channel subfamily K member 2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
IC50: 7.60E+3nM
Assay Description:
Inhibition of of human TREK1 expressed in CHO cells assessed as reduction in channel currents
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Target
Solute carrier family 22 member 1
(Homo sapiens (Human))
Uppsala University
Curated by
ChEMBL
Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
IC50: 1.11E+4nM
Assay Description:
Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy
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Target
Solute carrier family 22 member 1
(Homo sapiens (Human))
Uppsala University
Curated by
ChEMBL
Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
IC50: 1.55E+4nM
Assay Description:
Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 4 receptor
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Target
Cytochrome P450 2J2
(Homo sapiens (Human))
Tongji University
Curated by
ChEMBL
Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS method
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Target
Bile salt export pump
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
IC50: 5.37E+4nM
Assay Description:
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...
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Target
ATP-binding cassette sub-family C member 3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...
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ATP-binding cassette sub-family C member 4
(Homo sapiens (Human))
Amgen
Curated by
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Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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ATP-binding cassette sub-family C member 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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Target
Bile salt export pump
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...
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Target
Lanosterol 14-alpha demethylase
(Homo sapiens (Human))
Act
Curated by
ChEMBL
Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
IC50: >2.00E+5nM
Assay Description:
Inhibition of human CYP51 expressed in Topp 3 cells by lanosterol demethylase assay
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Target
ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
EC50: 329nM
Assay Description:
Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay
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Target
Nuclear receptor subfamily 2 group E member 1
(Homo sapiens)
Goethe-University Frankfurt
Curated by
ChEMBL
Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
EC50: 4.70E+4nM
Assay Description:
Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured afte...
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Target
ATP-dependent translocase ABCB1
(Homo sapiens (Human))
Bulgarian Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50067133
(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
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Affinity Data
EC50: 320nM
Assay Description:
Compound was tested for inhibition of daunomycin efflux in the resistant human T-lymphoblast cell line CEM vcr1000.
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