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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 11 hits in this display   

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084758(3-Hydroxycarbamoyl-4-(4-methoxy-benzenesulfonyl)-p...)
Affinity DataIC50:  0.600nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084758(3-Hydroxycarbamoyl-4-(4-methoxy-benzenesulfonyl)-p...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of recombinant human MMP9 using Mca-Pro-Leu-Dpa-Ala-Arg-NH2 as substrate incubated for 20 to 30 mins by fluorescence microplate reader ana...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCollagenase 3(Homo sapiens (Human))TBA
LigandPNGBDBM50084758(3-Hydroxycarbamoyl-4-(4-methoxy-benzenesulfonyl)-p...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of recombinant human MMP13 using Mca-Pro-Leu-Dpa-Ala-Arg-NH2 as substrate incubated for 20 to 30 mins by fluorescence microplate reader an...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCollagenase 3(Homo sapiens (Human))TBA
LigandPNGBDBM50084758(3-Hydroxycarbamoyl-4-(4-methoxy-benzenesulfonyl)-p...)
Affinity DataIC50:  0.700nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084758(3-Hydroxycarbamoyl-4-(4-methoxy-benzenesulfonyl)-p...)
Affinity DataIC50:  5.30nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084758(3-Hydroxycarbamoyl-4-(4-methoxy-benzenesulfonyl)-p...)
Affinity DataIC50:  5.30nMAssay Description:Binding affinity towards matrix metalloprotease-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084758(3-Hydroxycarbamoyl-4-(4-methoxy-benzenesulfonyl)-p...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of recombinant human MMP3 expressed in Escherichia coli BL21 (DE3) using [3H]transferrin as substrate incubated for 3 hrs by scintillation...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInterstitial collagenase(Homo sapiens (Human))TBA
LigandPNGBDBM50084758(3-Hydroxycarbamoyl-4-(4-methoxy-benzenesulfonyl)-p...)
Affinity DataIC50:  22nMAssay Description:Inhibition of recombinant human MMP1 expressed in Escherichia coli BL21 (DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate incubated for 20...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInterstitial collagenase(Homo sapiens (Human))TBA
LigandPNGBDBM50084758(3-Hydroxycarbamoyl-4-(4-methoxy-benzenesulfonyl)-p...)
Affinity DataIC50:  22nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084758(3-Hydroxycarbamoyl-4-(4-methoxy-benzenesulfonyl)-p...)
Affinity DataIC50:  483nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-7 (MMP-7)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084758(3-Hydroxycarbamoyl-4-(4-methoxy-benzenesulfonyl)-p...)
Affinity DataIC50:  483nMAssay Description:Inhibition of recombinant human MMP7 using Mca-Pro-Leu-Dpa-Ala-Arg-NH2 as substrate incubated for 20 to 30 mins by fluorescence microplate reader ana...More data for this Ligand-Target Pair
In DepthDetails PubMed