Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 47 hits in this display
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
Ki: 1.5nMAssay Description:Binding affinity to human N-terminal His6-tagged BRD4 BD1-BD2 (K57 to K550 residues) after 1 hr using alexa-647 conjugated probe by TR-FRET assayMore data for this Ligand-Target Pair
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
Ki: 2.09nMAssay Description:Compound dilution series were prepared in DMSO via an approximately 3-fold serial dilution. Compound dilutions were added directly into white, low-vo...More data for this Ligand-Target Pair
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
Ki: 3.5nM ΔG°: -48.3kJ/molepH: 6.0 T: 2°CAssay Description:A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...More data for this Ligand-Target Pair
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
IC50: 74nMAssay Description:Inhibition of BRD4-BD1 (44 to 168 residues) (unknown origin) using histone H4 peptide as substrate preincubated for 15 mins followed by addition of s...More data for this Ligand-Target Pair
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
Kd: >1.00E+3nMAssay Description:Binding affinity to human BAZ2B (S2054 to S2168 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
Kd: >1.00E+3nMAssay Description:Binding affinity to human PBRM1 bromodamian-5 (S645 to D766 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)
Kd: <10nMAssay Description:Binding affinity to N-terminal His6-tagged human BRD4 BD1 to BD2 (K57 to K550 residues) by isothermal titration calorimetryMore data for this Ligand-Target Pair
BDBM220447(US10633379, Compound X | US9296741, 36)
Kd: >1.00E+3nMAssay Description:Binding affinity to human TAF1L (2) (Q1523 to D1654 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM220447(US10633379, Compound X | US9296741, 36)
Kd: >1.00E+3nMAssay Description:Binding affinity to human SMARCA4 (A1448 to S1575 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM220447(US10633379, Compound X | US9296741, 36)
BDBM220447(US10633379, Compound X | US9296741, 36)