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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
9
hits in this display
Target
Nuclear receptor ROR-gamma
(Homo sapiens (Human))
Nestle Skin Health
Curated by
ChEMBL
Ligand
BDBM50461063
(CHEMBL4226803 | US10457637, Compound 8)
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Affinity Data
IC50: 17nM
Assay Description:
Inverse agonist activity at RORgamma in human CD4+ T cells assessed as inhibition of antiCD-28 antibody stimulated IL-17A production after 4 days by ...
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Target Info
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Ligand Info
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Details
Article
PubMed
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Target
Nuclear receptor ROR-gamma
(Homo sapiens (Human))
Nestle Skin Health
Curated by
ChEMBL
Ligand
BDBM50461063
(CHEMBL4226803 | US10457637, Compound 8)
Copy SMILES
Copy InChI
Affinity Data
IC50: 26nM
Assay Description:
Inverse agonist activity at RORgamma (unknown origin) expressed in human HeLa-derived HG5LN cells transfected with the GAL4 DNA-binding domain fused ...
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Target Info
PDB
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UniProtKB/SwissProt
antibodypedia
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Ligand Info
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PC sid
In Depth
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Article
PubMed
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Target
Nuclear receptor ROR-gamma
(Homo sapiens (Human))
Nestle Skin Health
Curated by
ChEMBL
Ligand
BDBM50461063
(CHEMBL4226803 | US10457637, Compound 8)
Copy SMILES
Copy InChI
Affinity Data
IC50: <100nM
Assay Description:
The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...
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US Patent
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Target
Interleukin-17A
(Homo sapiens (Human))
Galderma Research & Development
US Patent
Ligand
BDBM50461063
(CHEMBL4226803 | US10457637, Compound 8)
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Affinity Data
IC50: <100nM
Assay Description:
This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...
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US Patent
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Target
Nuclear receptor ROR-alpha
(Homo sapiens (Human))
Nestle Skin Health
Curated by
ChEMBL
Ligand
BDBM50461063
(CHEMBL4226803 | US10457637, Compound 8)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inverse agonist activity at RORalpha (unknown origin) expressed in human HeLa-derived HG5LN cells transfected with the GAL4 DNA-binding domain fused ...
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Target Info
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MMDB
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KEGG
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B.MOAD
antibodypedia
GoogleScholar
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PC sid
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Article
PubMed
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Target
Retinoic acid receptor gamma
(Homo sapiens (Human))
Nestle Skin Health
Curated by
ChEMBL
Ligand
BDBM50461063
(CHEMBL4226803 | US10457637, Compound 8)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inverse agonist activity at RARgamma (unknown origin) expressed in human HeLa-derived HG5LN cells transfected with the GAL4 DNA-binding domain fused ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
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Target
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human))
Nestle Skin Health
Curated by
ChEMBL
Ligand
BDBM50461063
(CHEMBL4226803 | US10457637, Compound 8)
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Affinity Data
Kd: >1.00E+4nM
Assay Description:
Activity at PPARgamma (unknown origin) expressed in human HeLa-derived HG5LN cells transfected with the GAL4 DNA-binding domain fused to the PPARgamm...
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Target Info
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NCI pathway
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KEGG
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antibodypedia
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PC sid
In Depth
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Article
PubMed
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Target
Vitamin D3 receptor
(Homo sapiens (Human))
Nestle Skin Health
Curated by
ChEMBL
Ligand
BDBM50461063
(CHEMBL4226803 | US10457637, Compound 8)
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Affinity Data
Kd: >1.00E+4nM
Assay Description:
Activity at VDR expressed in human HeLa-derived HDLN6 cells assessed as inhibition of transcriptional activity after 18 hrs by luminescence-based luc...
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Target Info
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KEGG
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antibodypedia
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PC sid
In Depth
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Article
PubMed
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Target
Oxysterols receptor LXR-beta
(Homo sapiens (Human))
Nestle Skin Health
Curated by
ChEMBL
Ligand
BDBM50461063
(CHEMBL4226803 | US10457637, Compound 8)
Copy SMILES
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Affinity Data
Kd: >1.00E+4nM
Assay Description:
Activity at LXRbeta (unknown origin) expressed in human HeLa-derived HG5LN cells transfected with the GAL4 DNA-binding domain fused to the LXRbeta li...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI