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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 9 hits in this display   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50461063(CHEMBL4226803 | US10457637, Compound 8)
Affinity DataIC50:  17nMAssay Description:Inverse agonist activity at RORgamma in human CD4+ T cells assessed as inhibition of antiCD-28 antibody stimulated IL-17A production after 4 days by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50461063(CHEMBL4226803 | US10457637, Compound 8)
Affinity DataIC50:  26nMAssay Description:Inverse agonist activity at RORgamma (unknown origin) expressed in human HeLa-derived HG5LN cells transfected with the GAL4 DNA-binding domain fused ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50461063(CHEMBL4226803 | US10457637, Compound 8)
Affinity DataIC50: <100nMAssay Description:The RORγ transactivation model was developed from the line HG5LN, which is a HeLa line that stably expresses a luciferase reporter gene controll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-17A(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM50461063(CHEMBL4226803 | US10457637, Compound 8)
Affinity DataIC50: <100nMAssay Description:This model allows measurement of the effect of inhibitors on IL-17A secretion by CD4+ cells. The cells are frozen CD4+ cells (STEMCELL, #70026), isol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-alpha(Homo sapiens (Human))
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50461063(CHEMBL4226803 | US10457637, Compound 8)
Affinity DataIC50: >1.00E+4nMAssay Description:Inverse agonist activity at RORalpha (unknown origin) expressed in human HeLa-derived HG5LN cells transfected with the GAL4 DNA-binding domain fused ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50461063(CHEMBL4226803 | US10457637, Compound 8)
Affinity DataIC50: >1.00E+4nMAssay Description:Inverse agonist activity at RARgamma (unknown origin) expressed in human HeLa-derived HG5LN cells transfected with the GAL4 DNA-binding domain fused ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50461063(CHEMBL4226803 | US10457637, Compound 8)
Affinity DataKd: >1.00E+4nMAssay Description:Activity at PPARgamma (unknown origin) expressed in human HeLa-derived HG5LN cells transfected with the GAL4 DNA-binding domain fused to the PPARgamm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50461063(CHEMBL4226803 | US10457637, Compound 8)
Affinity DataKd: >1.00E+4nMAssay Description:Activity at VDR expressed in human HeLa-derived HDLN6 cells assessed as inhibition of transcriptional activity after 18 hrs by luminescence-based luc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Nestle Skin Health

Curated by ChEMBL
LigandPNGBDBM50461063(CHEMBL4226803 | US10457637, Compound 8)
Affinity DataKd: >1.00E+4nMAssay Description:Activity at LXRbeta (unknown origin) expressed in human HeLa-derived HG5LN cells transfected with the GAL4 DNA-binding domain fused to the LXRbeta li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed