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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM278129(5-(4-((1-ethyl-1H-pyrazol-4-yl)amino)-1,3,5-triazi...)
Affinity DataIC50:  6nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM278129(5-(4-((1-ethyl-1H-pyrazol-4-yl)amino)-1,3,5-triazi...)
Affinity DataIC50:  9nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM278129(5-(4-((1-ethyl-1H-pyrazol-4-yl)amino)-1,3,5-triazi...)
Affinity DataIC50:  662nMAssay Description:Enzymatic activity of hJAK2 was measured using a LANCE homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that monitors...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM278129(5-(4-((1-ethyl-1H-pyrazol-4-yl)amino)-1,3,5-triazi...)
Affinity DataIC50:  6.00E+3nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM278129(5-(4-((1-ethyl-1H-pyrazol-4-yl)amino)-1,3,5-triazi...)
Affinity DataIC50:  9.00E+3nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM278129(5-(4-((1-ethyl-1H-pyrazol-4-yl)amino)-1,3,5-triazi...)
Affinity DataIC50:  6.62E+5nMpH: 7.5Assay Description:Enzymatic activity of hJAK2 was measured using a LANCE homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that monitors...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent