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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 11 hits in this display   

TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409513(2-[6-(5-Chloro-2-thienyl)pyrrolo[3,2-b]pyridin-1-y...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM409513(2-[6-(5-Chloro-2-thienyl)pyrrolo[3,2-b]pyridin-1-y...)
Affinity DataIC50:  6.30nMAssay Description:Modulation of recombinant human GluN1/GluN2B NMDA receptor expressed in mammalian cells assessed as inhibition of glutamate/glycine-induced intracell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM409513(2-[6-(5-Chloro-2-thienyl)pyrrolo[3,2-b]pyridin-1-y...)
Affinity DataIC50:  6.31nMAssay Description:The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM409513(2-[6-(5-Chloro-2-thienyl)pyrrolo[3,2-b]pyridin-1-y...)
Affinity DataIC50:  32nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409513(2-[6-(5-Chloro-2-thienyl)pyrrolo[3,2-b]pyridin-1-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]dofetilide from recombinant human ERG expressed in HEK293 cell membranes measured after 80 mins by TopCount scintillation analysi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409513(2-[6-(5-Chloro-2-thienyl)pyrrolo[3,2-b]pyridin-1-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409513(2-[6-(5-Chloro-2-thienyl)pyrrolo[3,2-b]pyridin-1-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409513(2-[6-(5-Chloro-2-thienyl)pyrrolo[3,2-b]pyridin-1-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409513(2-[6-(5-Chloro-2-thienyl)pyrrolo[3,2-b]pyridin-1-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409513(2-[6-(5-Chloro-2-thienyl)pyrrolo[3,2-b]pyridin-1-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409513(2-[6-(5-Chloro-2-thienyl)pyrrolo[3,2-b]pyridin-1-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed