Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 44 hits in this display
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
IC50: 25nMAssay Description:Concentration required to achieve 50% inhibition against 4-hydroxyphenylpyruvate dioxygenase from pig liver; (observed value)More data for this Ligand-Target Pair
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
IC50: 34nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
IC50: 61nMAssay Description:Inhibition of recombinant human His6-tagged PARP1 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll...More data for this Ligand-Target Pair
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
IC50: 62nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
IC50: 170nMAssay Description:Inhibition of PARP-1 (unknown origin) assessed as NAD+ consumption after 20 mins by fluorometric analysis in presence of activated DNAMore data for this Ligand-Target Pair
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
IC50: 382nMAssay Description:Inhibition of recombinant human His6-tagged PARP2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll...More data for this Ligand-Target Pair
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
IC50: 481nMAssay Description:Inhibition of recombinant human His6-tagged PARP1 C-3-zinc finger domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by...More data for this Ligand-Target Pair
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
IC50: 1.70E+3nMAssay Description:Inhibition of recombinant human TNKS1 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...More data for this Ligand-Target Pair
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
IC50: 5.89E+3nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...More data for this Ligand-Target Pair
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
IC50: 6.80E+3nMAssay Description:Inhibition of recombinant human His6-tagged PARP10 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol...More data for this Ligand-Target Pair
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
BDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)