Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 346 hits in this display
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 1.90nMAssay Description:Inhibition of human HDAC6 pre-incubated for 5 mins before substrate addition and measured after 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 13nMAssay Description:Inhibition of tubastatin-Alexa647-tracer binding to recombinant GST-tagged HDAC10 (unknown origin) measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 14nMAssay Description:Inhibition of human recombinant HDAC6 using ZMAL (Z-Lys(Ac)-AMC) fluorogenic substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 15nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 15nMAssay Description:Inhibition of human HDAC6 using p53 fluorogenic peptide (379 to 382 residues) RHKKAc as substrate by fluorescence-based assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 15nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 15nMAssay Description:Inhibition of recombiant human HDAC6 using fluorogenic HDAC substrate 3 measured after 30 mins by fluorescence microplate reader assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 15nMAssay Description:Inhibition of human recombinant HDAC6 using RHKKAc peptide as substrate incubated for 5 to mins prior to substrate addition measured after 2 hrsMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 21nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 insect cells pretreated with compound f...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >30nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >30nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >30nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >30nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >30nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >30nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >30nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >30nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 31nMAssay Description:Inhibition of HDAC6 in human HeLaS3 cells preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 45 mins by ELISAMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 35nMAssay Description:Inhibition of human recombinant HDAC6 expressed in baculovirus infected insect cells using BATCP as substrate after 4 hrs by UHPLC-ESI-MS/MS analysisMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 220nMAssay Description:Inhibition of zebra fish HDAC10 using Ac-spermidine-AMC as substrate incubated for 25 mins and measured by fluorescence assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 377nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 752nMAssay Description:Inhibition of human HDAC1 pre-incubated for 5 mins before substrate addition and measured after 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 770nMAssay Description:Inhibition of recombinant human KDAC3/NcoR2 using acetylated p53 (379 to 382 residues) as substrate by fluorescence assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 814nMpH: 8.0 T: 2°CAssay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 850nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 854nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 854nMAssay Description:Inhibition of full length C-terminal 6x-His tagged human HDAC8 using Arg-His-Lys(Ac)-Lys(Ac) substrate incubated for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 950nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 1.01E+3nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 1.27E+3nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 1.27E+3nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 1.40E+3nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 1.45E+3nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 1.48E+3nMAssay Description:Inhibition of Schistosoma mansoni KDAC8 using (FAM)-labeled peptide as substrate after 60 mins by microfluidic assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 1.91E+3nMAssay Description:Inhibition of recombinant human HDAC1 using ZMAL (Z-(Ac)Lys-AMC as substrate incubated for 20 mins and measured by homogenous fluorescence assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >2.00E+3nMAssay Description:Inhibition of HDAC1/HDAC2/HDAC3 in human HeLa nuclear extracts using MAL as substrate after 4 hrs by UHPLC-ESI-MS/MS analysisMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 2.34E+3nMAssay Description:Inhibition of recombinant human KDAC8 using diacetylated p53 (379 to 382 residues) as substrate by fluorescence assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 2.49E+3nMAssay Description:Inhibition of human recombinant HDAC1 using ZMAL (Z-Lys(Ac)-AMC) fluorogenic substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 2.70E+3nMAssay Description:Inhibition of full length his6/FLAG-tagged human recombinant HDAC1(1 to 482 residues) expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 2.70E+3nMAssay Description:Inhibition of HDAC1 in human HeLaS3 cells preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 45 mins by ELISAMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 2.87E+3nMAssay Description:Inhibition of recombinant human KDAC1 using acetylated p53 (379 to 382 residues) as substrate by fluorescence assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 2.90E+3nMAssay Description:Inhibition of full length C-terminal his6/FLAG-tagged human recombinant HDAC3 (1 to 2383 residues) expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 2.90E+3nMAssay Description:Inhibition of HDAC3 in human HeLaS3 cells preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 45 mins by ELISAMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 3.35E+3nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 3.67E+3nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 3.71E+3nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 3.79E+3nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 3.90E+3nMAssay Description:Inhibition of HDAC2 in human HeLaS3 cells preincubated for 15 mins followed by HDAC-Glo substrate addition measured after 30 to 45 mins by ELISAMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 4.31E+3nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 6.27E+3nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 7.05E+3nMAssay Description:Inhibition of recombinant human HDAC1 using Z-(Ac)-Lys-AMC as substrate incubated for 40 mins by fluorescence based assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 8.78E+3nMAssay Description:Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 9.70E+3nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 1.18E+4nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 1.38E+4nMpH: 8.0 T: 2°CAssay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 1.44E+4nMAssay Description:Inhibition of recombinant human HDAC1 using Fluor de Lys-SIRT1 as substrate incubated for 15 mins by fluorescence assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 1.50E+4nMAssay Description:Inhibition of full length human HDAC6 using FAM-labeled acetylated peptide as substrate by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 1.64E+4nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 1.64E+4nMAssay Description:Inhibition of human HDAC1 using p53 fluorogenic peptide (379 to 382 residues) RHKKAc as substrate by fluorescence-based assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 1.64E+4nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 1.64E+4nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 1.64E+4nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 1.64E+4nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 1.64E+4nMAssay Description:Inhibition of human recombinant HDAC1 using RHKKAc peptide as substrate incubated for 5 to mins prior to substrate addition measured after 2 hrsMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 1.64E+4nMAssay Description:Inhibition of human recombinant HDAC1 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrateMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 1.64E+4nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 1.64E+4nMAssay Description:Inhibition of full length GST-tagged human HDAC1 using Arg-His-Lys-Lys(Ac) substrate incubated for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 1.73E+4nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 1.97E+4nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 2.54E+4nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >3.00E+4nMAssay Description:Inhibition of HDAC4 (unknown origin) using Acetyl-Lys(trifluoroacetyl)-AMC fluorogenic peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >3.00E+4nMAssay Description:Inhibition of HDAC5 (unknown origin) using Acetyl-Lys(trifluoroacetyl)-AMC fluorogenic peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >3.00E+4nMAssay Description:Inhibition of HDAC7 (unknown origin) using Acetyl-Lys(trifluoroacetyl)-AMC fluorogenic peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >3.00E+4nMAssay Description:Inhibition of HDAC9 (unknown origin) using Acetyl-Lys(trifluoroacetyl)-AMC fluorogenic peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >3.00E+4nMAssay Description:Inhibition of human HDAC2 using p53 fluorogenic peptide (379 to 382 residues) RHKKAc as substrate by fluorescence-based assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >3.00E+4nMpH: 8.0 T: 2°CAssay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >3.00E+4nMpH: 8.0 T: 2°CAssay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >3.00E+4nMpH: 8.0 T: 2°CAssay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >3.00E+4nMpH: 8.0 T: 2°CAssay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >3.00E+4nMpH: 8.0 T: 2°CAssay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >3.00E+4nMpH: 8.0 T: 2°CAssay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >3.00E+4nMpH: 8.0 T: 2°CAssay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >3.00E+4nMpH: 8.0 T: 2°CAssay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >3.00E+4nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >3.00E+4nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >3.00E+4nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >3.00E+4nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >3.00E+4nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >3.00E+4nMAssay Description:Inhibition of full length C-terminal 6x-His tagged human HDAC2 using Arg-His-Lys-Lys(Ac) substrate incubated for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >3.00E+4nMAssay Description:Inhibition of full length C-terminal 6x-His tagged human HDAC3 using Arg-His-Lys-Lys(Ac) substrate incubated for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >3.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC10 (1 to 481 residues) using Arg-His-Lys-Lys(Ac) substrate incubated for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: >3.00E+4nMAssay Description:Inhibition of full length N-terminal GST-tagged human HDAC11 using Arg-His-Lys-Lys(Ac) substrate incubated for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 3.84E+4nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
IC50: 8.17E+4nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
BDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
EC50: 1.09E+3nMAssay Description:Inhibition of HDAC6 in human RPMI-8226 cells assessed as increase in tubulin acetylation incubated for 6 hrs by Western blot analysisMore data for this Ligand-Target Pair
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