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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 11 hits in this display   

TargetInsulin-degrading enzyme(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant IDE-mediated amyloid beta (16 to 23) hydrolysis using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substrate p...More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)
Affinity DataIC50:  100nMAssay Description:Inhibition of IDE exosite and catalytic site (unknown origin)More data for this Ligand-Target Pair
TargetInsulin-degrading enzyme(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of human recombinant IDE-mediated amyloid beta (1 to 40) hydrolysis preincubated for 10 mins measured after 30 mins by spectrophotometer a...More data for this Ligand-Target Pair
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant ECE1-mediated amyloid beta hydrolysis after 45 mins by fluorimetry assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human NEP-mediated amyloid beta hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ACE-mediated amyloid beta hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant ACE2-mediated amyloid beta hydrolysis using Mca-Tyr-Val-Ala-Asp-Pro-Ala-Lys-(DNP)-OH as substrate after 20 mins by fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant TACE-mediated amyloid beta hydrolysis after 5 mins by fluorimetry assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant MMP1-mediated amyloid beta hydrolysis using DNP-Pro-Cha-Gly- Cys(Me)-His-Ala- Lys(n-Me-Abz)-NH2 as substrate after 40...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant MMP13-mediated amyloid beta hydrolysis after 10 mins by fluorimetry assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-degrading enzyme(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)
Affinity DataEC50:  530nMAssay Description:Induction of human recombinant IDE-mediated insulin hydrolysis preincubated for 10 mins measured after 30 mins by spectrophotometer analysisMore data for this Ligand-Target Pair