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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM117012(US8637532, 739)
Affinity DataIC50:  0.600nMpH: 7.5 T: 2°CAssay Description:P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM117012(US8637532, 739)
Affinity DataIC50:  4nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM117012(US8637532, 739)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM117012(US8637532, 739)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed