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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 8 hits in this display   

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50210054((R,E)-3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropa...)
Affinity DataIC50:  610nMAssay Description:Inhibition of human recombinant MMP9 catalytic domain incubated for 20 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50210054((R,E)-3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropa...)
Affinity DataIC50:  2.75E+3nMAssay Description:Inhibition of human recombinant MMP12 catalytic domain incubated for 20 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50210054((R,E)-3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropa...)
Affinity DataIC50:  3.58E+3nMAssay Description:Inhibition of human recombinant MMP2 catalytic domain incubated for 20 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50210054((R,E)-3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropa...)
Affinity DataIC50:  1.47E+4nMAssay Description:Inhibition of human recombinant MMP1 catalytic domain using Dnp-Pro-beta-cyclohexyl-Ala-Gly-Cys(Me)-His-Lys-(Nma)-NH2 as substrate preincubated with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50210054((R,E)-3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropa...)
Affinity DataIC50:  1.47E+4nMAssay Description:Inhibition of human recombinant MMP1 catalytic domain incubated for 20 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50210054((R,E)-3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropa...)
Affinity DataIC50:  2.83E+4nMAssay Description:Inhibition of human recombinant MMP3 catalytic domain incubated for 20 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50210054((R,E)-3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropa...)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of human recombinant MMP13 catalytic domain incubated for 20 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Rattus norvegicus (Rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50210054((R,E)-3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropa...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of gelatinolytic activity of MMP2 in rat lung homogenate after 40 mins by SDS-PAGE preincubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed