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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 8 hits in this display   

TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598016(CHEMBL5170047)
Affinity DataIC50:  550nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT7 (2 to 692 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598016(CHEMBL5170047)
Affinity DataIC50:  2.14E+3nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT4 (2 to 608 residues) using histone H3 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598016(CHEMBL5170047)
Affinity DataIC50:  1.17E+4nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT1 (2 to 371 residues) using histone H4 as substrate incubated for 20 mins in presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598016(CHEMBL5170047)
Affinity DataIC50:  1.87E+4nMAssay Description:Inhibition of human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 3(Homo sapiens)
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598016(CHEMBL5170047)
Affinity DataIC50:  4.34E+4nMAssay Description:Inhibition of human full length recombinant GST his-tagged PRMT3 (2 to 531 residues) using histone H4 as substrate incubated for 20 mins in presence ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598016(CHEMBL5170047)
Affinity DataIC50:  7.67E+4nMAssay Description:Inhibition of human full length recombinant FLAG-tagged PRMT5 (2 to 637 residues) using histone H2A as substrate incubated for 20 mins in presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetProtein arginine N-methyltransferase 6(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598016(CHEMBL5170047)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human full length recombinant GST-tagged PRMT6 (2 to 375 residues) using GST-GAR as substrate incubated for 20 mins in presence of [3H]...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Institut De G£N£Tique Et De Biologie Mol£Culaire Et Cellulaire

Curated by ChEMBL
LigandPNGBDBM50598016(CHEMBL5170047)
Affinity DataKd:  2.30E+3nMAssay Description:Binding affinity to full length recombinant PRMT4 (unknown origin) assessed as dissociation constant by surface plasmon resonanceMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB