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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 18 hits in this display   

TargetCyclin-T1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM126547(US8778951, 358)
Affinity DataIC50:  0.000170nMAssay Description:Cdk9/cyclinT1 is purchased from Millipore, cat #14-685. The final total protein concentration in the assay 4 nM. The 5TAMRA-cdk7tide peptide substrat...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-T1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM126500(US11591322, Compound NVP-2 | US8778951, 310)
Affinity DataIC50:  0.000300nMAssay Description:Cdk9/cyclinT1 is purchased from Millipore, cat #14-685. The final total protein concentration in the assay 4 nM. The 5TAMRA-cdk7tide peptide substrat...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM126500(US11591322, Compound NVP-2 | US8778951, 310)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM126500(US11591322, Compound NVP-2 | US8778951, 310)
Affinity DataIC50: <0.514nMAssay Description:Effective concentration required for inhibitory activity towards human beta-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-K(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM126500(US11591322, Compound NVP-2 | US8778951, 310)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged CDK9/cyclinK expressed in baculovirus infected Sf9 insect cells using PDKtide as su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Algen Biotechnologies

US Patent
LigandPNGBDBM126500(US11591322, Compound NVP-2 | US8778951, 310)
Affinity DataIC50:  3.75nMAssay Description:To each well of a 96-well plate was added 5× kinase assay buffer with 10 mM DTT (6 μL), 500 μM ATP (1 μL), 5×CDK substrate (10 μL...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM126500(US11591322, Compound NVP-2 | US8778951, 310)
Affinity DataIC50:  350nMAssay Description:Effective concentration required for inhibitory activity towards human beta-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM126500(US11591322, Compound NVP-2 | US8778951, 310)
Affinity DataIC50:  584nMAssay Description:Effective concentration required for inhibitory activity towards human beta-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 16(Homo sapiens (Human))TBA
LigandPNGBDBM126500(US11591322, Compound NVP-2 | US8778951, 310)
Affinity DataIC50:  605nMAssay Description:Effective concentration required for inhibitory activity towards human beta-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM126500(US11591322, Compound NVP-2 | US8778951, 310)
Affinity DataIC50:  706nMAssay Description:Effective concentration required for inhibitory activity towards human beta-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))TBA
LigandPNGBDBM126500(US11591322, Compound NVP-2 | US8778951, 310)
Affinity DataIC50:  1.05E+3nMAssay Description:Effective concentration required for inhibitory activity towards human beta-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 17(Homo sapiens (Human))TBA
LigandPNGBDBM126500(US11591322, Compound NVP-2 | US8778951, 310)
Affinity DataIC50:  1.50E+3nMAssay Description:Effective concentration required for inhibitory activity towards human beta-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 14(Homo sapiens (Human))TBA
LigandPNGBDBM126500(US11591322, Compound NVP-2 | US8778951, 310)
Affinity DataIC50:  3.45E+3nMAssay Description:Effective concentration required for inhibitory activity towards human beta-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM126500(US11591322, Compound NVP-2 | US8778951, 310)
Affinity DataIC50:  3.46E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged CDK2/cyclinA2 expressed in baculovirus infected Sf9 insect cells using histone H1 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 18(Homo sapiens)TBA
LigandPNGBDBM126500(US11591322, Compound NVP-2 | US8778951, 310)
Affinity DataIC50:  4.90E+3nMAssay Description:Effective concentration required for inhibitory activity towards human beta-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))TBA
LigandPNGBDBM126500(US11591322, Compound NVP-2 | US8778951, 310)
Affinity DataIC50: >1.00E+4nMAssay Description:Effective concentration required for inhibitory activity towards human beta-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM126500(US11591322, Compound NVP-2 | US8778951, 310)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged CDK6/cyclinD3 expressed in baculovirus infected Sf9 insect cells using histone H1 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))TBA
LigandPNGBDBM126500(US11591322, Compound NVP-2 | US8778951, 310)
Affinity DataIC50: >1.00E+4nMAssay Description:Effective concentration required for inhibitory activity towards human beta-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed