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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
5
hits in this display
Target
A disintegrin and metalloproteinase with thrombospondin motifs 6
(Human)
Galapagos
US Patent
Ligand
BDBM429790
(5-[3-[4-(4- chloro-3- methoxy-5- methyl- phenyl)-1...)
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Affinity Data
IC50: 12.5nM
Assay Description:
The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...
More data for this Ligand-Target Pair
Target Info
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UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
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Details
US Patent
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Target
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human))
Galapagos
US Patent
Ligand
BDBM429790
(5-[3-[4-(4- chloro-3- methoxy-5- methyl- phenyl)-1...)
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Affinity Data
IC50: 37.5nM
Assay Description:
The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by human ADAMTS-5.For the dose res...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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Target
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human))
Galapagos
US Patent
Ligand
BDBM429790
(5-[3-[4-(4- chloro-3- methoxy-5- methyl- phenyl)-1...)
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Affinity Data
IC50: 75nM
Assay Description:
The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEMS INC...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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Target
Collagenase 3
(Homo sapiens (Human))
Galapagos
US Patent
Ligand
BDBM429790
(5-[3-[4-(4- chloro-3- methoxy-5- methyl- phenyl)-1...)
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Affinity Data
IC50: >100nM
Assay Description:
The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat# AS-27076) by human MMP13 (Chemicon, Cat#CC068).For th...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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Target
Matrix metalloproteinase-14
(Homo sapiens (Human))
Galapagos
US Patent
Ligand
BDBM429790
(5-[3-[4-(4- chloro-3- methoxy-5- methyl- phenyl)-1...)
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Copy InChI
Affinity Data
IC50: >100nM
Assay Description:
The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat# AS-27076) by human MMP14 (Biomol, Cat#SE-259).For the...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI