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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 13 hits in this display   

TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
Stc.Unm

US Patent
LigandPNGBDBM191763(US10669227, Compound Curcumin | US11608309, Compou...)
Affinity DataIC50:  8.20E+3nMAssay Description:The NF-kB activities of curcumin and analogs were determined by a cellular firefly luciferase assay. This assay utilized a commercially available cel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM191763(US10669227, Compound Curcumin | US11608309, Compou...)
Affinity DataIC50:  1.40E+4nMAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM191763(US10669227, Compound Curcumin | US11608309, Compou...)
Affinity DataIC50:  1.40E+4nMT: 2°CAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM191763(US10669227, Compound Curcumin | US11608309, Compou...)
Affinity DataIC50:  1.40E+4nMAssay Description:Table 1 shows the IC50 of curcumin, compound 1, and compound 2, compared to a standard Zn++ binding & MMPI (matrix metalloproteinase inhibitor), 1,10...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM191763(US10669227, Compound Curcumin | US11608309, Compou...)
Affinity DataIC50:  2.90E+4nMT: 2°CAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM191763(US10669227, Compound Curcumin | US11608309, Compou...)
Affinity DataIC50:  2.90E+4nMAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM191763(US10669227, Compound Curcumin | US11608309, Compou...)
Affinity DataIC50:  2.90E+4nMAssay Description:Table 1 shows the IC50 of curcumin, compound 1, and compound 2, compared to a standard Zn++ binding & MMPI (matrix metalloproteinase inhibitor), 1,10...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target72 kDa type IV collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM191763(US10669227, Compound Curcumin | US11608309, Compou...)
Affinity DataIC50:  8.50E+4nMAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target72 kDa type IV collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM191763(US10669227, Compound Curcumin | US11608309, Compou...)
Affinity DataIC50:  8.50E+4nMT: 2°CAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target72 kDa type IV collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM191763(US10669227, Compound Curcumin | US11608309, Compou...)
Affinity DataIC50:  8.50E+4nMAssay Description:Table 10: The efficacy of MMP-2 inhibition was as follows: compound 6>compound 7>compound 8. Although compound 6 showed similar efficacy as curcumin ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCollagenase 3(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM191763(US10669227, Compound Curcumin | US11608309, Compou...)
Affinity DataIC50:  1.10E+5nMAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCollagenase 3(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM191763(US10669227, Compound Curcumin | US11608309, Compou...)
Affinity DataIC50:  1.10E+5nMAssay Description:Table 10: The efficacy of MMP-2 inhibition was as follows: compound 6>compound 7>compound 8. Although compound 6 showed similar efficacy as curcumin ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCollagenase 3(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM191763(US10669227, Compound Curcumin | US11608309, Compou...)
Affinity DataIC50:  1.10E+5nMT: 2°CAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails US Patent