Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 10 hits in this display
BDBM429741(5-(3-(4-(4,5- dichloro-2- methoxyphenyl) piperidin...)
BDBM429772((5R)-5-[3-[4- (4,5-dichloro- 2-methoxy- phenyl)-1-...)
IC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
BDBM429772((5R)-5-[3-[4- (4,5-dichloro- 2-methoxy- phenyl)-1-...)
BDBM429741(5-(3-(4-(4,5- dichloro-2- methoxyphenyl) piperidin...)
BDBM429772((5R)-5-[3-[4- (4,5-dichloro- 2-methoxy- phenyl)-1-...)
IC50: >100nMAssay Description:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat# AS-27076) by human MMP13 (Chemicon, Cat#CC068).For th...More data for this Ligand-Target Pair
BDBM429741(5-(3-(4-(4,5- dichloro-2- methoxyphenyl) piperidin...)
BDBM429772((5R)-5-[3-[4- (4,5-dichloro- 2-methoxy- phenyl)-1-...)
IC50: >100nMAssay Description:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat# AS-27076) by human MMP14 (Biomol, Cat#SE-259).For the...More data for this Ligand-Target Pair
BDBM429772((5R)-5-[3-[4- (4,5-dichloro- 2-methoxy- phenyl)-1-...)
BDBM429741(5-(3-(4-(4,5- dichloro-2- methoxyphenyl) piperidin...)
IC50: >100nMAssay Description:The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by human ADAMTS-5.For the dose res...More data for this Ligand-Target Pair
BDBM429741(5-(3-(4-(4,5- dichloro-2- methoxyphenyl) piperidin...)
IC50: >100nMAssay Description:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEMS INC...More data for this Ligand-Target Pair