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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 9 hits in this display   

TargetELAV-like protein 3(Homo sapiens)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM23410(2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of ELAV3 (unknown origin)-artificial ARE complex formation after 30 mins in the presence of biotin-labeled RNA probe by chemiluminescence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol hexakisphosphate kinase 2(Homo sapiens)
National Institute Of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM23410(2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of human IP6K2 using insP6 as substrate preincubated for 15 mins followed by substrate and measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))TBA
LigandPNGBDBM23410(2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of amyloid beta (1 to 42) (unknown origin) fibril formation incubated for 1 hr by thioflavin-T fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
King'S College London

Curated by ChEMBL
LigandPNGBDBM23410(2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of human recombinant aldose reductase using D-glyceraldehyde as substrate preincubated for 10 mins before substrate addition measured for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol polyphosphate multikinase(Homo sapiens)
National Institute Of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM23410(2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human IPMK using insP3 as substrate preincubated for 15 mins followed by substrate and measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM23410(2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H...)
Affinity DataIC50:  2.87E+4nMAssay Description:IC50 was measured as concentration required to inhibit 50% of HIV-integrase integrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM23410(2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H...)
Affinity DataIC50:  6.16E+4nMAssay Description:IC50 was measured as concentration required to inhibit 50% of HIV-integrase cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic alpha-amylase(Sus scrofa (Pig))
Universit£

Curated by ChEMBL
LigandPNGBDBM23410(2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H...)
Affinity DataIC50:  7.39E+4nMAssay Description:Inhibition of hog pancreas alpha-amylase using starch as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-amylase 1A(Homo sapiens (Human))
Nestle Research Center

LigandPNGBDBM23410(2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H...)
Affinity DatapH: 6.0 T: 2°CAssay Description:The assay was carried out at room temperature for 10 min with salivary alpha-amylase, starch, and test compounds. The reducing sugar was determined b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed