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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 10 hits in this display   

TargetCyclin-G-associated kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524287(CHEMBL4462395)
Affinity DataKi:  2.50E+3nMAssay Description:Binding affinity to C-terminal AVI-tagged GAK (unknown origin) (12 to 347 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 16(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524287(CHEMBL4462395)
Affinity DataKi:  1.50E+4nMAssay Description:Binding affinity to C-terminal AVI-tagged STK16 (unknown origin) (13 to 305 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524287(CHEMBL4462395)
Affinity DataKi:  7.80E+4nMAssay Description:Binding affinity to C-terminal AVI-tagged AAK1 (unknown origin) (31 to 396 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBMP-2-inducible protein kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524287(CHEMBL4462395)
Affinity DataKi:  9.50E+4nMAssay Description:Binding affinity to C-terminal AVI-tagged BMP2K (unknown origin) (38 to 345 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524287(CHEMBL4462395)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524287(CHEMBL4462395)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of GAK (unknown origin) by in-cell pulse based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 3(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524287(CHEMBL4462395)
Affinity DataKd:  740nMAssay Description:Binding affinity to human IRAK3 (147 to 596 residues) expressed in bacterial expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524287(CHEMBL4462395)
Affinity DataKd:  2.50E+6nMAssay Description:Binding affinity to GAK (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524287(CHEMBL4462395)
Affinity DataKd:  9.90E+3nMAssay Description:Binding affinity to human wild type partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by KinomeScan methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 3(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524287(CHEMBL4462395)
Affinity DataKd:  480nMAssay Description:Binding affinity to human wild type partial length IRAK3 (V147 to E596 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed