Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 49 hits in this display
BDBM179481(US9675697, Cpd. No. 73)
BDBM179481(US9675697, Cpd. No. 73)
BDBM179481(US9675697, Cpd. No. 73)
Ki: 7.80nM ΔG°: -46.3kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
BDBM179481(US9675697, Cpd. No. 73)
BDBM179481(US9675697, Cpd. No. 73)
Ki: 8.70nM ΔG°: -46.0kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
Ki: 10nM ΔG°: -45.7kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
Ki: 16nM ΔG°: -44.5kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
Ki: 35nM ΔG°: -42.6kJ/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
IC50: 7.20nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human N-terminal His6-tagged BRD4 bromodomain 2 (333 to 460 residues) expressed in Rosetta2 D...More data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
IC50: 28nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human N-terminal His6-tagged BRD4 bromodomain 1 (44 to 168 residues) expressed in Rosetta2 DE...More data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
IC50: 28nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human BRD4 bromodomain 1 (44 to 168 residues) expressed in Rosetta2 Escherichia coli DE3 cell...More data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
BDBM179481(US9675697, Cpd. No. 73)
Kd: 550nMAssay Description:Binding affinity to human partial length EP300 (A1040 to G1161 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
Kd: >4.00E+3nMAssay Description:Binding affinity to human partial length ATAD2A (Q981 to R1108 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
Kd: >4.00E+3nMAssay Description:Binding affinity to human partial length BRD8 bromodomain 1 (S700 to F854 residues) expressed in mammalian expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
Kd: >4.00E+3nMAssay Description:Binding affinity to human partial length BRD1 (E556 to A688 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
Kd: >4.00E+3nMAssay Description:Binding affinity to human partial length BRPF3 (E588 to G701 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
Kd: >4.00E+3nMAssay Description:Binding affinity to human partial length FALZ (S2791 to H2911 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
Kd: >4.00E+3nMAssay Description:Binding affinity to human partial length PBRM1 bromodomain 2 (S178 to E291 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
Kd: >4.00E+3nMAssay Description:Binding affinity to human partial length PCAF (G715 to D831 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
Kd: >4.00E+3nMAssay Description:Binding affinity to human partial length SMARCA2 (S1377 to Q1486 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
Kd: >4.00E+3nMAssay Description:Binding affinity to human partial length TAF1 bromodomain 2 (D1521 to D1656 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
BDBM179481(US9675697, Cpd. No. 73)
BDBM179481(US9675697, Cpd. No. 73)
Kd: >4.00E+3nMAssay Description:Binding affinity to human partial length BAZ2B (S2054 to S2168 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
Kd: >4.00E+3nMAssay Description:Binding affinity to human partial length BRD7 (L125 to R254 residues) expressed in mammalian expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
Kd: >4.00E+3nMAssay Description:Binding affinity to human partial length BRD9 (R130 to V259 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
Kd: >4.00E+3nMAssay Description:Binding affinity to human partial length PBRM1 bromodomain 5 (S645 to D766 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
Kd: >4.00E+3nMAssay Description:Binding affinity to human partial length SMARCA4 (A1448 to S1575 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
BDBM179481(US9675697, Cpd. No. 73)
BDBM179481(US9675697, Cpd. No. 73)
BDBM179481(US9675697, Cpd. No. 73)
Kd: 520nMAssay Description:Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
Kd: >4.00E+3nMAssay Description:Binding affinity to human partial length ATAD2B (Q955 to R1082 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
Kd: 1.60E+3nMAssay Description:Binding affinity to human partial length CECR2 (P423 to D543 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
BDBM179481(US9675697, Cpd. No. 73)
BDBM179481(US9675697, Cpd. No. 73)
BDBM179481(US9675697, Cpd. No. 73)
Kd: 0.690nMAssay Description:Binding affinity to human partial length BRD3 bromodomain 2 (G306 to P416 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
Kd: 2nMAssay Description:Binding affinity to human partial length BRD3 bromodomain 1 (P24 to E144 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
BDBM179481(US9675697, Cpd. No. 73)
BDBM179481(US9675697, Cpd. No. 73)
Kd: >4.00E+3nMAssay Description:Binding affinity to human partial length BAZ2A (M1792 to L1905 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
Kd: >4.00E+3nMAssay Description:Binding affinity to human partial length GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
Kd: 0.730nMAssay Description:Binding affinity to human partial length BRD3 bromodomain 1/2 (P24 to P416 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
Kd: >4.00E+3nMAssay Description:Binding affinity to human partial length WDR9 bromodomain 2 (A1310 to E1430 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
Kd: >4.00E+3nMAssay Description:Binding affinity to human partial length BRPF1 (E627 to G740 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
BDBM179481(US9675697, Cpd. No. 73)
Kd: >4.00E+3nMAssay Description:Binding affinity to human partial length BRD8 bromodomain 2 (D1095 to F1235 residues) expressed in mammalian expression system by BROMOscan assayMore data for this Ligand-Target Pair