Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Gsk

LigandBDBM27446(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(oxola...)Copy SMILESCopy InChI

Affinity DataIC50:  251nMpH: 7.2 T: 2°CAssay Description:The compound inhibitory activity was determined by incubation with purified PLK1 and biotinylated peptide substrate in the presence ATP/[gamma-33P]AT...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Gsk

LigandBDBM27446(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(oxola...)Copy SMILESCopy InChI

Affinity DataIC50: >1.58E+4nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Gsk

LigandBDBM27446(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(oxola...)Copy SMILESCopy InChI

Affinity DataIC50: >1.58E+4nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair

Target InfoPDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI