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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 11 hits in this display   

TargetHistone deacetylase 6(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50504581(CHEMBL4554522)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of human HDAC6 using Arg-His-Lys-Lys (Ac) as substrate incubated for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50504581(CHEMBL4554522)
Affinity DataIC50:  34nMAssay Description:Inhibition of human HDAC3 using Arg-His-Lys-Lys (Ac) as substrate incubated for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50504581(CHEMBL4554522)
Affinity DataIC50:  896nMAssay Description:Inhibition of human HDAC1 using Arg-His-Lys-Lys (Ac) as substrate incubated for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50504581(CHEMBL4554522)
Affinity DataIC50:  1.13E+3nMAssay Description:Inhibition of human HDAC2 using Arg-His-Lys-Lys (Ac) as substrate incubated for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50504581(CHEMBL4554522)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of human HDAC8 using Arg-His-Lys (Ac)-Lys (Ac) as substrate incubated for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50504581(CHEMBL4554522)
Affinity DataIC50:  1.81E+3nMAssay Description:Inhibition of human HDAC11 using Acetyl-Lys (trifluoroacetyl)-AMC) as substrate incubated for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50504581(CHEMBL4554522)
Affinity DataIC50:  2.69E+3nMAssay Description:Inhibition of human HDAC10 using Acetyl-Lys (trifluoroacetyl)-AMC) as substrate incubated for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50504581(CHEMBL4554522)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human DNMT1 using Poly(dI-dC) as substrate incubated for 1 hr in presence of [3H]-SAM by filter binding methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 3A(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50504581(CHEMBL4554522)
Affinity DataIC50:  7.40E+4nMAssay Description:Inhibition of human DNMT3a using lambda DNA as substrate incubated for 1 hr in presence of [3H]-SAM by filter binding methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50504581(CHEMBL4554522)
Affinity DataEC50:  1.42E+5nMAssay Description:Inhibition of human G9a using core histone H3 (1 to 21 residues) as substrate incubated for 1 hr in presence of [3H]-SAM by filter binding methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1/2/3(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50504581(CHEMBL4554522)
Affinity DataEC50:  7.50E+3nMAssay Description:Inhibition of HDAC1/2/3 in human KMS-12-BM cells assessed as increase in Ac-H3 level incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed