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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 27 hits in this display   

TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataKi:  38nMAssay Description:Inhibition of human GSK-3beta using biotin-AAEELDSRAGS(PO3H2)PQL as substrate after 20 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataKi:  38nMAssay Description:Inhibition of GSK3-betaChecked by AuthorMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataKi:  770nMAssay Description:Inhibition of GSK-3beta using phospho-glycogen synthase peptide-2 as substrate after 10 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50:  42nMAssay Description:Inhibition of human GSK3-beta by scintillation countingMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50:  72nMAssay Description:Inhibition of recombinant human GSK3beta using prephosphorylated peptide as substrate measured after 30 mins by Kinase-glo luminescence assayMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant human GSK3beta using biotin-AAEELDSRAGS(PO3H2)PQL as substrate preincubated for 10 to 15 mins followed by [gamma33P]ATP add...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Mus musculus)
Peking University

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human GSK-3beta in mouse 3T3 fibroblasts stably expressing four-repeat tau protein assessed as reduction in tau S396 phosphorylation af...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Stellenbosch University

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50:  104nMAssay Description:Inhibition of recombinant human GSK3alpha/beta using biotin-AAEELDSRAGS(PO3H2)PQL as substrate preincubated for 10 to 15 mins followed by [gamma-33P]...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50:  104nMAssay Description:Inhibition of recombinant full length human GSK3beta expressed in Sf21 insect cells using biotinylated-AAEELDSRAGS(PO3H2)PQL peptide as substrate pre...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50:  104nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50:  104nMAssay Description:Inhibition of human recombinant GSK3betaMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50:  104nMAssay Description:Inhibition of GSK3betaMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50:  104nMAssay Description:Inhibition of GSK3-betaChecked by AuthorMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50:  220nMAssay Description:Inhibition of human GSK-3beta using YRRAAVPPSPSLSRHSSPHQS(p) EDEEE substrate peptide and [gamma-33P-ATP] incubated for 40 mins by scintillation count...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50:  490nMAssay Description:Inhibition of human recombinant GSK-3beta using prephosphorylated polypeptide as substrate incubated for 30 mins in presence of ATP by Kinase-Glo lum...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Mus musculus (mouse))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of mouse AChE using acetylthiocholine iodide as substrate incubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Technische Universit£T Darmstadt

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of human GSK3alpha activity using Ser/Thr 11 peptide as substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Cdk2Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of CDK2 at 10 mMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Cdk5Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
The Rockefeller University

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of CDK5 at 10 mMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50:  3.30E+5nMAssay Description:Inhibition of human GSK3-beta activity using Ser/Thr 9 peptide as substrate by FRET assayMore data for this Ligand-Target Pair
TargetProtein kinase C alpha type(Homo sapiens (Human))
Technische Universit£T Darmstadt

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50: >1.00E+8nMAssay Description:Inhibition of human PKCalpha activity using Ser/Thr 7 peptide as substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Technische Universit£T Darmstadt

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50: >1.00E+8nMAssay Description:Inhibition of human CDK5/p35 activity using Ser/Thr 12 peptide as substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Technische Universit£T Darmstadt

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50: >1.00E+8nMAssay Description:Inhibition of human AURKA activity using Ser/Thr 1 peptide as substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
Technische Universit£T Darmstadt

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50: >1.00E+8nMAssay Description:Inhibition of human CKI epsilon activity using Ser/Thr 11 peptide as substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed