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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
27
hits in this display
Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
University Of Toronto
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 38nM
Assay Description:
Inhibition of human GSK-3beta using biotin-AAEELDSRAGS(PO3H2)PQL as substrate after 20 mins by liquid scintillation counting
More data for this Ligand-Target Pair
Target Info
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Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
University Of Toronto
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 38nM
Assay Description:
Inhibition of GSK3-beta
Checked by Author
More data for this Ligand-Target Pair
Target Info
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Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
University Of Toronto
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 770nM
Assay Description:
Inhibition of GSK-3beta using phospho-glycogen synthase peptide-2 as substrate after 10 mins by liquid scintillation counting
More data for this Ligand-Target Pair
Target Info
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Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
University Of Toronto
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 42nM
Assay Description:
Inhibition of human GSK3-beta by scintillation counting
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
University Of Toronto
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 72nM
Assay Description:
Inhibition of recombinant human GSK3beta using prephosphorylated peptide as substrate measured after 30 mins by Kinase-glo luminescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
University Of Toronto
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 100nM
Assay Description:
Inhibition of recombinant human GSK3beta using biotin-AAEELDSRAGS(PO3H2)PQL as substrate preincubated for 10 to 15 mins followed by [gamma33P]ATP add...
More data for this Ligand-Target Pair
Target Info
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Target
Glycogen synthase kinase-3 beta
(Mus musculus)
Peking University
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
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Affinity Data
IC50: 100nM
Assay Description:
Inhibition of human GSK-3beta in mouse 3T3 fibroblasts stably expressing four-repeat tau protein assessed as reduction in tau S396 phosphorylation af...
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
University Of Toronto
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 100nM
Assay Description:
Inhibition of human GSK3beta
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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B.MOAD
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Ligand Info
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Target
Glycogen synthase kinase-3
(Homo sapiens (Human))
Stellenbosch University
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 104nM
Assay Description:
Inhibition of recombinant human GSK3alpha/beta using biotin-AAEELDSRAGS(PO3H2)PQL as substrate preincubated for 10 to 15 mins followed by [gamma-33P]...
More data for this Ligand-Target Pair
Target Info
PDB
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antibodypedia
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Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
University Of Toronto
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 104nM
Assay Description:
Inhibition of recombinant full length human GSK3beta expressed in Sf21 insect cells using biotinylated-AAEELDSRAGS(PO3H2)PQL peptide as substrate pre...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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Ligand Info
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CHEMBL
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In Depth
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PubMed
MMDB
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3D Structure (crystal)
Copy BDB DOI
Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
University Of Toronto
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 104nM
Assay Description:
Inhibition of GSK3-beta
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
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PC sid
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In Depth
Details
Article
PubMed
MMDB
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
University Of Toronto
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 104nM
Assay Description:
Inhibition of human recombinant GSK3beta
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
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MCE
MMDB
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In Depth
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PubMed
MMDB
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
University Of Toronto
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 104nM
Assay Description:
Inhibition of GSK3beta
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
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PC sid
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In Depth
Details
Article
PubMed
MMDB
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
University Of Toronto
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 104nM
Assay Description:
Inhibition of GSK3-beta
Checked by Author
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
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In Depth
Details
Article
PubMed
MMDB
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
University Of Toronto
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 220nM
Assay Description:
Inhibition of human GSK-3beta using YRRAAVPPSPSLSRHSSPHQS(p) EDEEE substrate peptide and [gamma-33P-ATP] incubated for 40 mins by scintillation count...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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MCE
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Article
PubMed
MMDB
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3D Structure (crystal)
Copy BDB DOI
Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
University Of Toronto
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 490nM
Assay Description:
Inhibition of human recombinant GSK-3beta using prephosphorylated polypeptide as substrate incubated for 30 mins in presence of ATP by Kinase-Glo lum...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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Copy BDB DOI
Target
Acetylcholinesterase
(Mus musculus (mouse))
China Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
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Affinity Data
IC50: >4.00E+4nM
Assay Description:
Inhibition of mouse AChE using acetylthiocholine iodide as substrate incubated for 20 mins by Ellman's method
More data for this Ligand-Target Pair
Target Info
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Target
Glycogen synthase kinase-3 alpha
(Homo sapiens (Human))
Technische Universit£T Darmstadt
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7.00E+4nM
Assay Description:
Inhibition of human GSK3alpha activity using Ser/Thr 11 peptide as substrate by FRET assay
More data for this Ligand-Target Pair
Target Info
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Target
Cyclin-dependent kinase 2
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of Cdk2
Checked by Author
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Cyclin-dependent kinase 2
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
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Affinity Data
IC50: 1.00E+5nM
Assay Description:
Inhibition of CDK2 at 10 mM
More data for this Ligand-Target Pair
Target Info
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Target
Cyclin-dependent kinase 5 activator 1
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of Cdk5
Checked by Author
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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B.MOAD
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Target
Cyclin-dependent kinase 5
(Homo sapiens (Human))
The Rockefeller University
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
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Affinity Data
IC50: 1.00E+5nM
Assay Description:
Inhibition of CDK5 at 10 mM
More data for this Ligand-Target Pair
Target Info
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Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
University Of Toronto
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.30E+5nM
Assay Description:
Inhibition of human GSK3-beta activity using Ser/Thr 9 peptide as substrate by FRET assay
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Protein kinase C alpha type
(Homo sapiens (Human))
Technische Universit£T Darmstadt
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
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Affinity Data
IC50: >1.00E+8nM
Assay Description:
Inhibition of human PKCalpha activity using Ser/Thr 7 peptide as substrate by FRET assay
More data for this Ligand-Target Pair
Target Info
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Target
Cyclin-dependent kinase 5 activator 1
(Homo sapiens (Human))
Technische Universit£T Darmstadt
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
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Affinity Data
IC50: >1.00E+8nM
Assay Description:
Inhibition of human CDK5/p35 activity using Ser/Thr 12 peptide as substrate by FRET assay
More data for this Ligand-Target Pair
Target Info
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Target
Aurora kinase A
(Homo sapiens (Human))
Technische Universit£T Darmstadt
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
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Affinity Data
IC50: >1.00E+8nM
Assay Description:
Inhibition of human AURKA activity using Ser/Thr 1 peptide as substrate by FRET assay
More data for this Ligand-Target Pair
Target Info
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Target
Casein kinase I isoform epsilon
(Homo sapiens (Human))
Technische Universit£T Darmstadt
Curated by
ChEMBL
Ligand
BDBM50229962
(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Copy SMILES
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Affinity Data
IC50: >1.00E+8nM
Assay Description:
Inhibition of human CKI epsilon activity using Ser/Thr 11 peptide as substrate by FRET assay
More data for this Ligand-Target Pair
Target Info
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