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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
4
hits in this display
Target
A disintegrin and metalloproteinase with thrombospondin motifs 5 [262-930,L692P]
(Homo sapiens (Human))
Wyeth Research
Ligand
BDBM24007
(1-benzyl-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)
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Affinity Data
IC50: 870nM
pH: 7.5 T: 2°C
Assay Description:
ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
PC cid
PC sid
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In Depth
Details
Article
PubMed
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Target
Macrophage metalloelastase
(Homo sapiens (Human))
Wyeth Research
Ligand
BDBM24007
(1-benzyl-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)
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Affinity Data
IC50: 5.60E+3nM
pH: 7.5 T: 2°C
Assay Description:
A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
A disintegrin and metalloproteinase with thrombospondin motifs 4
(Homo sapiens (Human))
Wyeth Research
Ligand
BDBM24007
(1-benzyl-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)
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Affinity Data
IC50: >2.20E+4nM
pH: 7.5 T: 2°C
Assay Description:
The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Collagenase 3
(Homo sapiens (Human))
Wyeth Research
Ligand
BDBM24007
(1-benzyl-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)
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Copy InChI
Affinity Data
IC50: >1.00E+5nM
pH: 7.5 T: 2°C
Assay Description:
A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI