Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

LigandPNGBDBM24007(1-benzyl-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)
Affinity DataIC50:  870nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM24007(1-benzyl-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)
Affinity DataIC50:  5.60E+3nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24007(1-benzyl-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)
Affinity DataIC50: >2.20E+4nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM24007(1-benzyl-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)
Affinity DataIC50: >1.00E+5nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed