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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
20
hits in this display
Target
Macrophage metalloelastase
(Homo sapiens (Human))
University Of Florence
Curated by
ChEMBL
Ligand
BDBM11328
(CHEMBL83508 | Hydroxamate 9 | N-hydroxy-2-[(4-meth...)
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Affinity Data
Ki: 20nM
Assay Description:
Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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PC sid
PDB
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PDB
3D Structure (crystal)
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Target
Carbonic anhydrase 4
(Bos taurus (bovine))
Universita Degli Studi
Ligand
BDBM11328
(CHEMBL83508 | Hydroxamate 9 | N-hydroxy-2-[(4-meth...)
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Affinity Data
Ki: 29nM
Assay Description:
Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
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CHEMBL
MMDB
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Universita Degli Studi
Ligand
BDBM11328
(CHEMBL83508 | Hydroxamate 9 | N-hydroxy-2-[(4-meth...)
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Affinity Data
Ki: 30nM ΔG°: -42.9kJ/mole
pH: 7.4 T: 2°C
Assay Description:
Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universita Degli Studi
Ligand
BDBM11328
(CHEMBL83508 | Hydroxamate 9 | N-hydroxy-2-[(4-meth...)
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Affinity Data
Ki: 32nM
Assay Description:
Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
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In Depth
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Article
PubMed
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Target
Interstitial collagenase
(Homo sapiens (Human))
De Novo Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM11328
(CHEMBL83508 | Hydroxamate 9 | N-hydroxy-2-[(4-meth...)
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Affinity Data
Ki: 33nM
Assay Description:
Binding affinity towards (MMP-1) matrix metalloproteinase-1
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Patents
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In Depth
Details
Article
PubMed
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Target
72 kDa type IV collagenase
(Homo sapiens (Human))
Pomona College
Curated by
ChEMBL
Ligand
BDBM11328
(CHEMBL83508 | Hydroxamate 9 | N-hydroxy-2-[(4-meth...)
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Affinity Data
Ki: 110nM
Assay Description:
Inhibition of MMP2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
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In Depth
Details
Article
PubMed
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Target
72 kDa type IV collagenase
(Homo sapiens (Human))
Pomona College
Curated by
ChEMBL
Ligand
BDBM11328
(CHEMBL83508 | Hydroxamate 9 | N-hydroxy-2-[(4-meth...)
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Affinity Data
Ki: 110nM
Assay Description:
Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
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PC sid
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In Depth
Details
Article
PubMed
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Target
Collagenase ColG
(Clostridium histolyticum)
Universita Degli Studi
Ligand
BDBM11328
(CHEMBL83508 | Hydroxamate 9 | N-hydroxy-2-[(4-meth...)
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Affinity Data
Ki: 120nM
Assay Description:
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Patents
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In Depth
Details
Article
PubMed
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Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Universita Degli Studi
Ligand
BDBM11328
(CHEMBL83508 | Hydroxamate 9 | N-hydroxy-2-[(4-meth...)
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Affinity Data
Ki: 143nM
Assay Description:
Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Universita Degli Studi
Ligand
BDBM11328
(CHEMBL83508 | Hydroxamate 9 | N-hydroxy-2-[(4-meth...)
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Affinity Data
Ki: 145nM
Assay Description:
Inhibition of MMP9
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
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PC sid
PDB
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In Depth
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Article
PubMed
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Target
Neutrophil collagenase
(Homo sapiens (Human))
Universita Degli Studi
Ligand
BDBM11328
(CHEMBL83508 | Hydroxamate 9 | N-hydroxy-2-[(4-meth...)
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Affinity Data
Ki: 155nM
Assay Description:
Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Interstitial collagenase
(Homo sapiens (Human))
De Novo Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM11328
(CHEMBL83508 | Hydroxamate 9 | N-hydroxy-2-[(4-meth...)
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Affinity Data
Ki: >200nM
Assay Description:
Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Patents
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In Depth
Details
Article
PubMed
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Target
Matrilysin
(Homo sapiens (Human))
University Of Florence
Curated by
ChEMBL
Ligand
BDBM11328
(CHEMBL83508 | Hydroxamate 9 | N-hydroxy-2-[(4-meth...)
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Affinity Data
Ki: 4.00E+3nM
Assay Description:
Inhibition of MMP7 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Patents
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In Depth
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Article
PubMed
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Target
Stromelysin-1
(Homo sapiens (Human))
Novartis Pharmaceuticals
Ligand
BDBM11328
(CHEMBL83508 | Hydroxamate 9 | N-hydroxy-2-[(4-meth...)
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Affinity Data
Ki: 4.40E+3nM
Assay Description:
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
72 kDa type IV collagenase
(Homo sapiens (Human))
Pomona College
Curated by
ChEMBL
Ligand
BDBM11328
(CHEMBL83508 | Hydroxamate 9 | N-hydroxy-2-[(4-meth...)
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Affinity Data
IC50: 32nM
Assay Description:
Inhibition of MMP2 by fluorometric assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Universita Degli Studi
Ligand
BDBM11328
(CHEMBL83508 | Hydroxamate 9 | N-hydroxy-2-[(4-meth...)
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Affinity Data
IC50: 130nM
Assay Description:
Inhibition of MMP9 by fluorometric assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
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PC sid
PDB
Patents
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In Depth
Details
Article
PubMed
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Target
Matrix metalloproteinase-14
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM11328
(CHEMBL83508 | Hydroxamate 9 | N-hydroxy-2-[(4-meth...)
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Affinity Data
IC50: 210nM
Assay Description:
Inhibition of human recombinant MMP14 by fluorometric assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM11328
(CHEMBL83508 | Hydroxamate 9 | N-hydroxy-2-[(4-meth...)
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Affinity Data
IC50: 1.80E+3nM
Assay Description:
Inhibition of human recombinant ADAM17 by fluorometric assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Interstitial collagenase
(Homo sapiens (Human))
De Novo Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM11328
(CHEMBL83508 | Hydroxamate 9 | N-hydroxy-2-[(4-meth...)
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Affinity Data
IC50: 3.00E+3nM
Assay Description:
Inhibition of MMP1 by fluorometric assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Meprin A subunit beta
(Homo sapiens)
Fraunhofer Institute For Cell Therapy and Immunology Izi
Curated by
ChEMBL
Ligand
BDBM11328
(CHEMBL83508 | Hydroxamate 9 | N-hydroxy-2-[(4-meth...)
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Affinity Data
IC50: 9.02E+3nM
Assay Description:
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI