Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 55 hits in this display
BDBM50003560(4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.0...)
BDBM213826(Dextromethorphan | US11535596, Compound Dextrometh...)
BDBM50003560(4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.0...)
BDBM50003560(4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.0...)
Ki: 63nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma-1 receptor in guinea pig brain membranes incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
BDBM213826(Dextromethorphan | US11535596, Compound Dextrometh...)
BDBM213826(Dextromethorphan | US11535596, Compound Dextrometh...)
BDBM50003560(4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.0...)
BDBM50003560(4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.0...)
BDBM50003560(4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.0...)
BDBM50003560(4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.0...)
BDBM50003560(4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.0...)
BDBM50003560(4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.0...)
BDBM213826(Dextromethorphan | US11535596, Compound Dextrometh...)
BDBM50003560(4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.0...)
BDBM213826(Dextromethorphan | US11535596, Compound Dextrometh...)
Ki: 4.52E+3nMAssay Description:In vitro binding assays for the phencyclidine site of NMDA-type glutamate receptors, and for sigma-1 receptors, both of which are known to be bound b...More data for this Ligand-Target Pair
BDBM50003560(4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.0...)
BDBM50003560(4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.0...)
BDBM213826(Dextromethorphan | US11535596, Compound Dextrometh...)
Ki: >1.00E+4nMAssay Description:Displacement of [3H]-Citalopram from NET (unknown origin) expressed in HEK cell membrane incubated for 2 hrs by liquid scintillation counter analysisMore data for this Ligand-Target Pair
BDBM213826(Dextromethorphan | US11535596, Compound Dextrometh...)
BDBM213826(Dextromethorphan | US11535596, Compound Dextrometh...)
IC50: 137nMAssay Description:In vitro binding assays for the phencyclidine site of NMDA-type glutamate receptors, and for sigma-1 receptors, both of which are known to be bound b...More data for this Ligand-Target Pair
BDBM50003560(4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.0...)
IC50: 1.80E+3nMAssay Description:Inhibition of MAMC O-dealkylation mediated by human Cytochrome P450 2D6 expressed in human lymphoblastoid cell lineMore data for this Ligand-Target Pair
BDBM50003560(4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.0...)
BDBM213826(Dextromethorphan | US11535596, Compound Dextrometh...)
IC50: 6.82E+3nMAssay Description:In vitro binding assays for the phencyclidine site of NMDA-type glutamate receptors, and for sigma-1 receptors, both of which are known to be bound b...More data for this Ligand-Target Pair
BDBM213826(Dextromethorphan | US11535596, Compound Dextrometh...)
IC50: 1.05E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
IC50: 1.11E+4nMAssay Description:Non-competitive inhibition of rat alpha3beta4 nAChR expressed in KX cells assessed as reduction in current by whole-cell patch clamp assayMore data for this Ligand-Target Pair
IC50: 1.50E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as reduction in ASP+ substrate uptake by microplate reader based analysisMore data for this Ligand-Target Pair
BDBM213826(Dextromethorphan | US11535596, Compound Dextrometh...)
BDBM213826(Dextromethorphan | US11535596, Compound Dextrometh...)
BDBM213826(Dextromethorphan | US11535596, Compound Dextrometh...)
BDBM213826(Dextromethorphan | US11535596, Compound Dextrometh...)
BDBM213826(Dextromethorphan | US11535596, Compound Dextrometh...)
BDBM50003560(4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.0...)
BDBM213826(Dextromethorphan | US11535596, Compound Dextrometh...)
BDBM213826(Dextromethorphan | US11535596, Compound Dextrometh...)
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