Home
About
Info
Download
WebServices
Contact
Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
9
hits in this display
Target
Tyrosine-protein kinase SYK
(Homo sapiens (Human))
Glaxosmithkline R&D
Curated by
ChEMBL
Ligand
BDBM50467630
(CHEMBL4291402)
Copy SMILES
Copy InChI
Affinity Data
IC50: 79nM
Assay Description:
Inhibition of recombinant human N-terminal His6-tagged SYK expressed in baculovirus expression system using Biotin-AAAEEIYGEI as substrate after 60 m...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
PDB
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Tyrosine-protein kinase SYK
(Homo sapiens (Human))
Glaxosmithkline R&D
Curated by
ChEMBL
Ligand
BDBM50467630
(CHEMBL4291402)
Copy SMILES
Copy InChI
Affinity Data
IC50: 200nM
Assay Description:
Inhibition of SYK in human Ramos B cells assessed as reduction in anti-human IgM Fab2 fragment-induced ERK phosphorylation preincubated for 30 mins f...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
PDB
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Tyrosine-protein kinase Lck
(Homo sapiens (Human))
Glaxosmithkline R&D
Curated by
ChEMBL
Ligand
BDBM50467630
(CHEMBL4291402)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.98E+3nM
Assay Description:
Inhibition of LCK (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
PDB
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Leucine-rich repeat serine/threonine-protein kinase 2
(Homo sapiens (Human))
Glaxosmithkline R&D
Curated by
ChEMBL
Ligand
BDBM50467630
(CHEMBL4291402)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.98E+3nM
Assay Description:
Inhibition of LRRK2 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
PDB
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
Glaxosmithkline R&D
Curated by
ChEMBL
Ligand
BDBM50467630
(CHEMBL4291402)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.01E+3nM
Assay Description:
Inhibition of GSK3beta (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
PDB
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Tyrosine-protein kinase JAK2
(Homo sapiens (Human))
Glaxosmithkline R&D
Curated by
ChEMBL
Ligand
BDBM50467630
(CHEMBL4291402)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.00E+4nM
Assay Description:
Inhibition of JAK2 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
PDB
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Aurora kinase B/Inner centromere protein
(Homo sapiens (Human))
Glaxosmithkline R&D
Curated by
ChEMBL
Ligand
BDBM50467630
(CHEMBL4291402)
Copy SMILES
Copy InChI
Affinity Data
IC50: <2.51E+4nM
Assay Description:
Inhibition of recombinant human FLAG/His6-tagged Aurora-B (2 to 344 residues)/GST-tagged INCENP preincubated for 30 mins followed by 5FAM-PKA-tide su...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
PDB
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human))
Glaxosmithkline R&D
Curated by
ChEMBL
Ligand
BDBM50467630
(CHEMBL4291402)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.16E+4nM
Assay Description:
Inhibition of VEGFR2 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
PDB
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Aurora kinase A
(Homo sapiens (Human))
Glaxosmithkline R&D
Curated by
ChEMBL
Ligand
BDBM50467630
(CHEMBL4291402)
Copy SMILES
Copy InChI
Affinity Data
IC50: <5.01E+4nM
Assay Description:
Inhibition of Aurora-A (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
PDB
In Depth
Details
Article
PubMed
Copy BDB DOI