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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human))
Galapagos
US Patent
Ligand
BDBM379630
(US9926281, Compound 146)
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Affinity Data
IC50: 70nM
Assay Description:
ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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Target
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human))
Galapagos
US Patent
Ligand
BDBM379630
(US9926281, Compound 146)
Copy SMILES
Copy InChI
Affinity Data
IC50: 89nM
Assay Description:
ADAMTS-5:Protocol 1: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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Target
ADAMTS5
(Rattus norvegicus (Rat))
Galapagos
US Patent
Ligand
BDBM379630
(US9926281, Compound 146)
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Affinity Data
IC50: 133nM
Assay Description:
ADAMTS-4:The basis for the assay is the cleavage of the substrate TBIS-1 (5-FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMTS4For the do...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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Target
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human))
Galapagos
US Patent
Ligand
BDBM379630
(US9926281, Compound 146)
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Affinity Data
IC50: 1.58E+3nM
Assay Description:
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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Target
Collagenase 3
(Homo sapiens (Human))
Galapagos
US Patent
Ligand
BDBM379630
(US9926281, Compound 146)
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Affinity Data
IC50: 3.88E+3nM
Assay Description:
MMP-13:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat # AS-27076) by human MMP13 (Chemicon, Cat #CC06...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
72 kDa type IV collagenase
(Homo sapiens (Human))
Galapagos
US Patent
Ligand
BDBM379630
(US9926281, Compound 146)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
MMP2: Protocol 2: The basis for the assay is the cleavage of the substrate 390 MMP FRET substrate I (Anaspec, Catalog n#: AS-27076) by human MMP2 (R&...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI