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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
4
hits in this display
Target
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human))
Abbvie S.á.R.L.
US Patent
Ligand
BDBM300428
(BDBM300430 | US10130622, Example 00007)
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Affinity Data
IC50: 138nM
Assay Description:
For this purpose, HEK293 cells are transfected with plasmid DNA containing WT CFTR and seeded in 96 well plates (70,000 HEK cells/well). Two days aft...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Cystic fibrosis transmembrane conductance regulator [G550E]
(Homo sapiens (Human))
Abbvie S.á.R.L.
US Patent
Ligand
BDBM300428
(BDBM300430 | US10130622, Example 00007)
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Affinity Data
IC50: 496nM
Assay Description:
YFP-Halide Influx Assay for the CFTR-ΔF508 Mutation and Suppressor mutants (I539T or G550E)The YFP halide influx assay measures the functionalit...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human))
Abbvie S.á.R.L.
US Patent
Ligand
BDBM300428
(BDBM300430 | US10130622, Example 00007)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.25E+3nM
Assay Description:
For this purpose, HEK293 cells are transfected with plasmid DNA containing WT CFTR and seeded in 96 well plates (70,000 HEK cells/well). Two days aft...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human))
Abbvie S.á.R.L.
US Patent
Ligand
BDBM300428
(BDBM300430 | US10130622, Example 00007)
Copy SMILES
Copy InChI
Affinity Data
Kd: 20.2nM
Assay Description:
To measure the direct binding of small molecules with CFTR, the interaction between small molecules and membrane fragments derived from HEK293 cells ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI