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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 18 hits in this display   

TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Riken

Curated by ChEMBL
LigandPNGBDBM50427989(CHEMBL2325503)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Riken

Curated by ChEMBL
LigandPNGBDBM50427989(CHEMBL2325503)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Oslo University Hospital

Curated by ChEMBL
LigandPNGBDBM50427989(CHEMBL2325503)
Affinity DataIC50:  25nMAssay Description:Inhibition of TNKS2 (unknown origin) by NAD+-dependent autopoly(ADP ribosyl)lation assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Riken

Curated by ChEMBL
LigandPNGBDBM50427989(CHEMBL2325503)
Affinity DataIC50:  27nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Riken

Curated by ChEMBL
LigandPNGBDBM50427989(CHEMBL2325503)
Affinity DataIC50:  27nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Oslo University Hospital

Curated by ChEMBL
LigandPNGBDBM50427989(CHEMBL2325503)
Affinity DataIC50:  46nMAssay Description:Inhibition of TNSK1 (unknown origin) by NAD+-dependent autopoly(ADP ribosyl)lation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Oslo University Hospital

Curated by ChEMBL
LigandPNGBDBM50427989(CHEMBL2325503)
Affinity DataIC50:  58nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Oslo University Hospital

Curated by ChEMBL
LigandPNGBDBM50427989(CHEMBL2325503)
Affinity DataIC50:  58nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Oslo University Hospital

Curated by ChEMBL
LigandPNGBDBM50427989(CHEMBL2325503)
Affinity DataIC50:  86nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 ARC5-SAM-PARP domain (613 to 1166 residues) expressed i...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Oslo University Hospital

Curated by ChEMBL
LigandPNGBDBM50427989(CHEMBL2325503)
Affinity DataIC50:  86nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 SAM-PARP domain (613 to 1166 residues) expressed in Esc...More data for this Ligand-Target Pair
TargetSulfotransferase 2A1(Homo sapiens (Human))TBA
LigandPNGBDBM50427989(CHEMBL2325503)
Affinity DataIC50:  1.01E+3nMAssay Description:Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Oslo University Hospital

Curated by ChEMBL
LigandPNGBDBM50427989(CHEMBL2325503)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Riken

Curated by ChEMBL
LigandPNGBDBM50427989(CHEMBL2325503)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells assessed as reduction in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50427989(CHEMBL2325503)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human PARP1 expressed in Escherichia coli assessed as reduction in auto-PARylation using histone as substrate measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Riken

Curated by ChEMBL
LigandPNGBDBM50427989(CHEMBL2325503)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells assessed as reduction in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50427989(CHEMBL2325503)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant N-terminal TEV-cleavgae site-fused-FLAG/Polyhis-tagged PARP10 (2 to 583 residues) expressed in Escherichia coli asses...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50427989(CHEMBL2325503)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human PARP1 expressed in Escherichia coli assessed as reduction in auto-PARylation using histone as substrate measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50427989(CHEMBL2325503)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant N-terminal TEV-cleavgae site-fused-FLAG/Polyhis-tagged PARP10 (2 to 583 residues) expressed in Escherichia coli asses...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed