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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 8 hits in this display   

TargetMatrilysin(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50589870(CHEMBL5202455)
Affinity DataIC50:  120nMAssay Description:Inhibition of human recombinant MMP-7 (Leu18 to Lys267 residues) using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as fluorogenic substrate preincuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetMacrophage metalloelastase(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50589870(CHEMBL5202455)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human recombinant MMP-12 (Leu17 to Cys470 residues) using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as fluorogenic substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50589870(CHEMBL5202455)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of human recombinant C-terminal 10-His tagged MMP-14 ( Ala21 to Gly284 residues) using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Target72 kDa type IV collagenase(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50589870(CHEMBL5202455)
Affinity DataIC50:  7.30E+4nMAssay Description:Inhibition of human recombinant MMP-2 ( Ile34 to Cys660 residues) using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as fluorogenic substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetCollagenase 3(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50589870(CHEMBL5202455)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant MMP-13 (Leu20 to Cys471 residues) using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as fluorogenic substrate preincub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50589870(CHEMBL5202455)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant MMP-9 (Ala20 to Asp707 residues) using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as fluorogenic substrate preincuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetStromelysin-1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50589870(CHEMBL5202455)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant MMP-3 (Tyr18 to Cys477 residues ) using MOCAc-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 as fluorogenic substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetNeutrophil collagenase(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50589870(CHEMBL5202455)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant MMP-8 (Phe21 to Gly467 residues) using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as fluorogenic substrate preincuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed