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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 7 hits in this display   

TargetNeutrophil collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM26789(benzimidazole analog., 15 | tert-butyl (3S,4S)-3-(...)
Affinity DataKi:  1.96E+3nM ΔG°:  -32.6kJ/molepH: 7.5 T: 25°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Human)
Bristol-Myers Squibb

LigandPNGBDBM26789(benzimidazole analog., 15 | tert-butyl (3S,4S)-3-(...)
Affinity DataKi:  4.08E+3nM ΔG°:  -30.8kJ/molepH: 7.5 T: 25°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Human)
Bristol-Myers Squibb

LigandPNGBDBM26789(benzimidazole analog., 15 | tert-butyl (3S,4S)-3-(...)
Affinity DataKi: >4.50E+3nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Human)
Bristol-Myers Squibb

LigandPNGBDBM26789(benzimidazole analog., 15 | tert-butyl (3S,4S)-3-(...)
Affinity DataKi: >5.03E+3nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26789(benzimidazole analog., 15 | tert-butyl (3S,4S)-3-(...)
Affinity DataIC50: <1nMpH: 7.5 T: 25°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Human)
Bristol-Myers Squibb

LigandPNGBDBM26789(benzimidazole analog., 15 | tert-butyl (3S,4S)-3-(...)
Affinity DataIC50:  540nMpH: 7.5 T: 25°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-2(Human)
Bristol-Myers Squibb

LigandPNGBDBM26789(benzimidazole analog., 15 | tert-butyl (3S,4S)-3-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed