Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 12 hits in this display
BDBM50200975(CHEMBL3916621 | US10087187, Compound 2)
IC50: 138nMAssay Description:Inhibition of PI3Kbeta in human PC3 cells assessed as suppression of AKT phosphorylation at Ser473 after 60 mins by ELISAMore data for this Ligand-Target Pair
BDBM50200975(CHEMBL3916621 | US10087187, Compound 2)
IC50: 186nMAssay Description:Inhibition of PI3Kbeta in human PC3 cells assessed as suppression of AKT phosphorylation at Thr308 after 60 mins by ELISAMore data for this Ligand-Target Pair
BDBM50200975(CHEMBL3916621 | US10087187, Compound 2)
BDBM50200975(CHEMBL3916621 | US10087187, Compound 2)
BDBM50200975(CHEMBL3916621 | US10087187, Compound 2)
BDBM50200975(CHEMBL3916621 | US10087187, Compound 2)
Kd: 8.13E+3nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
BDBM50200975(CHEMBL3916621 | US10087187, Compound 2)
Kd: 1.40nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
BDBM50200975(CHEMBL3916621 | US10087187, Compound 2)
Kd: 178nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
BDBM50200975(CHEMBL3916621 | US10087187, Compound 2)
Kd: >3.02E+4nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...More data for this Ligand-Target Pair
BDBM50200975(CHEMBL3916621 | US10087187, Compound 2)
Kd: 8.13E+3nMAssay Description:Binding affinity to human PI3Kalpha (108 to 1068 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
BDBM50200975(CHEMBL3916621 | US10087187, Compound 2)
BDBM50200975(CHEMBL3916621 | US10087187, Compound 2)
Kd: >3.02E+4nMAssay Description:Binding affinity to human PI3Kgamma (144 to 1102 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair