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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
25
hits in this display
Target
Fatty acid synthase
(Homo sapiens (Human))
Indiana University School Of Medicine
Curated by
ChEMBL
Ligand
BDBM50070208
(A-65006 | AG-1749 | CHEBI:6375 | Lansoprazole | Pr...)
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Affinity Data
Ki: 1.70E+3nM
Assay Description:
Inhibition of human FASN enoyl reductase activity using crotonyl CoA as substrate assessed as inhibition of substrate hydrolysis measured every 1 min...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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Target
Fatty acid synthase
(Homo sapiens (Human))
Indiana University School Of Medicine
Curated by
ChEMBL
Ligand
BDBM50070208
(A-65006 | AG-1749 | CHEBI:6375 | Lansoprazole | Pr...)
Copy SMILES
Affinity Data
Ki: 5.30E+3nM
Assay Description:
Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition meas...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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Article
PubMed
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Target
Potassium-transporting ATPase alpha chain 1/subunit beta
(Homo sapiens (Human))
Byk Gulden Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50070208
(A-65006 | AG-1749 | CHEBI:6375 | Lansoprazole | Pr...)
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Affinity Data
IC50: 398nM
Assay Description:
In vitro evaluation for the inhibition of H+/K+ ATPase at pH < 3 in the gastric glands of isolated rabbit stomach.
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
antibodypedia
GoogleScholar
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Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50070208
(A-65006 | AG-1749 | CHEBI:6375 | Lansoprazole | Pr...)
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Affinity Data
IC50: 2.90E+3nM
Assay Description:
Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 8 mins by LC-MS/MS analysis
More data for this Ligand-Target Pair
Target Info
PDB
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Article
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Target
Cytochrome P450 2C8
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50070208
(A-65006 | AG-1749 | CHEBI:6375 | Lansoprazole | Pr...)
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Affinity Data
IC50: 5.75E+3nM
Assay Description:
Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 8 mins by LC-MS/MS analysis
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
Ligand Info
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Article
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Target
Cytochrome P450 1A2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50070208
(A-65006 | AG-1749 | CHEBI:6375 | Lansoprazole | Pr...)
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Affinity Data
IC50: 6.46E+3nM
Assay Description:
Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 8 mins by LC-MS/MS analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
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Article
PubMed
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Target
Cytochrome P450 2C19
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50070208
(A-65006 | AG-1749 | CHEBI:6375 | Lansoprazole | Pr...)
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Affinity Data
IC50: 1.34E+4nM
Assay Description:
Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate after 8 mins by LC-MS/MS analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
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Target
Broad substrate specificity ATP-binding cassette transporter ABCG2
(Homo sapiens (Human))
Federal University Of Parana
Curated by
ChEMBL
Ligand
BDBM50070208
(A-65006 | AG-1749 | CHEBI:6375 | Lansoprazole | Pr...)
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Affinity Data
IC50: 1.44E+4nM
Assay Description:
Inhibition of human ABCG2 expressed in human HEK293 cells membrane vesicles mediated transport of 3[H]-MTX for 2 mins using [3H]-methotrexate as subs...
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
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Ligand Info
PC cid
PC sid
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PubMed
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Target
Cytochrome P450 2C9
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50070208
(A-65006 | AG-1749 | CHEBI:6375 | Lansoprazole | Pr...)
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Affinity Data
IC50: 1.92E+4nM
Assay Description:
Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 8 mins by LC-MS/MS analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
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Article
PubMed
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Target
Cytosolic endo-beta-N-acetylglucosaminidase
(Homo sapiens (Human))
University of Utah
Curated by
ChEMBL
Ligand
BDBM50070208
(A-65006 | AG-1749 | CHEBI:6375 | Lansoprazole | Pr...)
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Affinity Data
IC50: 2.44E+4nM
Assay Description:
Inhibition of recombinant human C-MYC/DDK-tagged ENGase expressed in HEK293T cells using heat inactivated bovine ribonuclease B as substrate pretreat...
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
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Target
Cytosolic endo-beta-N-acetylglucosaminidase
(Homo sapiens (Human))
University of Utah
Curated by
ChEMBL
Ligand
BDBM50247930
(Dexilant | Dexilant solutab | Dexlansoprazole | Ka...)
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Affinity Data
IC50: 2.50E+4nM
Assay Description:
Inhibition of recombinant human C-MYC/DDK-tagged ENGase expressed in HEK293T cells using heat inactivated bovine ribonuclease B as substrate pretreat...
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50070208
(A-65006 | AG-1749 | CHEBI:6375 | Lansoprazole | Pr...)
Copy SMILES
Affinity Data
IC50: >3.00E+4nM
Assay Description:
Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 8 mins by LC-MS/MS analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Fatty acid synthase
(Homo sapiens (Human))
Indiana University School Of Medicine
Curated by
ChEMBL
Ligand
BDBM50070208
(A-65006 | AG-1749 | CHEBI:6375 | Lansoprazole | Pr...)
Copy SMILES
Affinity Data
IC50: 4.67E+4nM
Assay Description:
Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition meas...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 2J2
(Homo sapiens (Human))
Tongji University
Curated by
ChEMBL
Ligand
BDBM50070208
(A-65006 | AG-1749 | CHEBI:6375 | Lansoprazole | Pr...)
Copy SMILES
Affinity Data
IC50: >5.00E+4nM
Assay Description:
Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS method
More data for this Ligand-Target Pair
Target Info
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Fatty acid synthase
(Homo sapiens (Human))
Indiana University School Of Medicine
Curated by
ChEMBL
Ligand
BDBM50070208
(A-65006 | AG-1749 | CHEBI:6375 | Lansoprazole | Pr...)
Copy SMILES
Affinity Data
IC50: 9.30E+4nM
Assay Description:
Inhibition of FASN in human PANC1 cells assessed as inhibition of [14C]acetate incorporation preincubated for 4 hrs before [14C]acetate addition meas...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Fatty acid synthase
(Homo sapiens (Human))
Indiana University School Of Medicine
Curated by
ChEMBL
Ligand
BDBM50070208
(A-65006 | AG-1749 | CHEBI:6375 | Lansoprazole | Pr...)
Copy SMILES
Affinity Data
IC50: 1.24E+5nM
Assay Description:
Inhibition of FASN in human BxPC3 cells assessed as inhibition of [14C]acetate incorporation preincubated for 4 hrs before [14C]acetate addition meas...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
ATP-binding cassette sub-family C member 3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50070208
(A-65006 | AG-1749 | CHEBI:6375 | Lansoprazole | Pr...)
Copy SMILES
Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
ATP-binding cassette sub-family C member 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50070208
(A-65006 | AG-1749 | CHEBI:6375 | Lansoprazole | Pr...)
Copy SMILES
Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
ATP-binding cassette sub-family C member 4
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50070208
(A-65006 | AG-1749 | CHEBI:6375 | Lansoprazole | Pr...)
Copy SMILES
Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
ATP-binding cassette sub-family C member 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50247930
(Dexilant | Dexilant solutab | Dexlansoprazole | Ka...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50247930
(Dexilant | Dexilant solutab | Dexlansoprazole | Ka...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
ATP-binding cassette sub-family C member 4
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50247930
(Dexilant | Dexilant solutab | Dexlansoprazole | Ka...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50070208
(A-65006 | AG-1749 | CHEBI:6375 | Lansoprazole | Pr...)
Copy SMILES
Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
ATP-binding cassette sub-family C member 3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50247930
(Dexilant | Dexilant solutab | Dexlansoprazole | Ka...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50070208
(A-65006 | AG-1749 | CHEBI:6375 | Lansoprazole | Pr...)
Copy SMILES
Affinity Data
IC50: >1.35E+5nM
Assay Description:
Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI