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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
8
hits in this display
Target
A disintegrin and metalloproteinase with thrombospondin motifs 4
(Human)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50345504
(CHEMBL1784360 | N-hydroxy-N-(4-((4-(2-methyl-4-(me...)
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Affinity Data
IC50: 5.80nM
Assay Description:
Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
A disintegrin and metalloproteinase with thrombospondin motifs 4
(Human)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50345504
(CHEMBL1784360 | N-hydroxy-N-(4-((4-(2-methyl-4-(me...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.80nM
Assay Description:
Protein concentrations were measured using the Micro BCA Protein Assay Kit (Pierce/Thermo Scientific, IL). Sample buffer was mixed with 5-25 μg ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
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Target
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Human)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50345504
(CHEMBL1784360 | N-hydroxy-N-(4-((4-(2-methyl-4-(me...)
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Affinity Data
IC50: 530nM
Assay Description:
Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Collagenase 3
(Human)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50345504
(CHEMBL1784360 | N-hydroxy-N-(4-((4-(2-methyl-4-(me...)
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Affinity Data
IC50: 1.70E+3nM
Assay Description:
Inhibition of recombinant human MMP-13 assessed as substrate cleavage after 20 hrs by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
72 kDa type IV collagenase
(Human)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50345504
(CHEMBL1784360 | N-hydroxy-N-(4-((4-(2-methyl-4-(me...)
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Affinity Data
IC50: 3.30E+3nM
Assay Description:
Inhibition of recombinant human MMP-2 assessed as substrate cleavage after 20 hrs by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Matrix metalloproteinase-9
(Human)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50345504
(CHEMBL1784360 | N-hydroxy-N-(4-((4-(2-methyl-4-(me...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human MMP-9 assessed as substrate cleavage after 20 hrs by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Interstitial collagenase
(Human)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50345504
(CHEMBL1784360 | N-hydroxy-N-(4-((4-(2-methyl-4-(me...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human MMP-1 assessed as substrate cleavage after 20 hrs by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Matrix metalloproteinase-14
(Human)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50345504
(CHEMBL1784360 | N-hydroxy-N-(4-((4-(2-methyl-4-(me...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human MMP-14 assessed as substrate cleavage after 20 hrs by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI