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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 8 hits in this display   

LigandPNGBDBM50345504(CHEMBL1784360 | N-hydroxy-N-(4-((4-(2-methyl-4-(me...)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50345504(CHEMBL1784360 | N-hydroxy-N-(4-((4-(2-methyl-4-(me...)
Affinity DataIC50:  5.80nMAssay Description:Protein concentrations were measured using the Micro BCA Protein Assay Kit (Pierce/Thermo Scientific, IL). Sample buffer was mixed with 5-25 μg ...More data for this Ligand-Target Pair
In DepthDetails US Patent

LigandPNGBDBM50345504(CHEMBL1784360 | N-hydroxy-N-(4-((4-(2-methyl-4-(me...)
Affinity DataIC50:  530nMAssay Description:Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345504(CHEMBL1784360 | N-hydroxy-N-(4-((4-(2-methyl-4-(me...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of recombinant human MMP-13 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345504(CHEMBL1784360 | N-hydroxy-N-(4-((4-(2-methyl-4-(me...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of recombinant human MMP-2 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345504(CHEMBL1784360 | N-hydroxy-N-(4-((4-(2-methyl-4-(me...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human MMP-9 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345504(CHEMBL1784360 | N-hydroxy-N-(4-((4-(2-methyl-4-(me...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human MMP-1 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345504(CHEMBL1784360 | N-hydroxy-N-(4-((4-(2-methyl-4-(me...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human MMP-14 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed