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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
10
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Birla Institute of Technology
Ligand
BDBM50310190
(2-p-Tolyl-chromen-4-one | 2-p-tolyl-4H-chromen-4-o...)
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Affinity Data
Ki: 990nM
Assay Description:
The activities of recombinant hMAO-A and hMAO-B were determined using p-tyramine as common substrate and calculated as 0.18 +/- 0.01 nmol/mg/min (n =...
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Target
Amine oxidase [flavin-containing] A
(Homo sapiens (Human))
Birla Institute of Technology
Ligand
BDBM50310190
(2-p-Tolyl-chromen-4-one | 2-p-tolyl-4H-chromen-4-o...)
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Affinity Data
Ki: 3.32E+3nM
Assay Description:
The activities of recombinant hMAO-A and hMAO-B were determined using p-tyramine as common substrate and calculated as 0.18 +/- 0.01 nmol/mg/min (n =...
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50310190
(2-p-Tolyl-chromen-4-one | 2-p-tolyl-4H-chromen-4-o...)
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Affinity Data
IC50: 52nM
Assay Description:
Inhibition of human 6XHis-tagged TNKS1 SAM-ART domain (1030 to 1317 amino acid residues) by fluorescence assay
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50310190
(2-p-Tolyl-chromen-4-one | 2-p-tolyl-4H-chromen-4-o...)
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Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Birla Institute of Technology
Ligand
BDBM50310190
(2-p-Tolyl-chromen-4-one | 2-p-tolyl-4H-chromen-4-o...)
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Affinity Data
IC50: 2.38E+3nM
Assay Description:
Inhibition of human recombinant MAOB expressed in BTI-TN-5B1-4 cells by para-tyramine oxidation assay
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50310190
(2-p-Tolyl-chromen-4-one | 2-p-tolyl-4H-chromen-4-o...)
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Affinity Data
IC50: 7.08E+3nM
Assay Description:
Inhibition of human full length ARTD1 using NAD+ as substrate by fluorescence assay
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50310190
(2-p-Tolyl-chromen-4-one | 2-p-tolyl-4H-chromen-4-o...)
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Affinity Data
IC50: 7.10E+3nM
Assay Description:
Inhibition of human full length ARTD1 using NAD+ as substrate by fluorescence assay
More data for this Ligand-Target Pair
Target Info
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MMDB
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PubMed
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50310190
(2-p-Tolyl-chromen-4-one | 2-p-tolyl-4H-chromen-4-o...)
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Affinity Data
IC50: 2.50E+4nM
Assay Description:
Inhibition of human recombinant ARTD1 by fluorescence assay
More data for this Ligand-Target Pair
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50310190
(2-p-Tolyl-chromen-4-one | 2-p-tolyl-4H-chromen-4-o...)
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Affinity Data
IC50: 2.75E+4nM
Assay Description:
Inhibition of human full length ARTD2 using NAD+ as substrate by fluorescence assay
More data for this Ligand-Target Pair
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
University Of Oulu
Curated by
ChEMBL
Ligand
BDBM50310190
(2-p-Tolyl-chromen-4-one | 2-p-tolyl-4H-chromen-4-o...)
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Affinity Data
IC50: 2.78E+4nM
Assay Description:
Inhibition of human full length ARTD2 using NAD+ as substrate by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MMDB
PC cid
PC sid
PDB
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI