Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50324734(7,9-Dimethyl-6-(5-methyl-furan-2-yl)-11-phenyl-6,7...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human CFTR expressed in rat FRT cells assessed as inhibition of CPT-cAMP-induced apical membrane current in presence of transepithelial...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50324734(7,9-Dimethyl-6-(5-methyl-furan-2-yl)-11-phenyl-6,7...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells assessed as inhibition of forskolin-induced short-circuit current by voltage clamp electrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50324734(7,9-Dimethyl-6-(5-methyl-furan-2-yl)-11-phenyl-6,7...)
Affinity DataIC50:  250nMAssay Description:Inhibition of human wild-type CFTR expressed in FRT cells coexpressing YFP-H148Q assessed as inhibition of cAMP agonist-induced iodide influx after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50324734(7,9-Dimethyl-6-(5-methyl-furan-2-yl)-11-phenyl-6,7...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human CFTR expressed in rat FRT cells coexpressing halide indicator YFP-H148Q assessed as inhibition of halide influx preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50324734(7,9-Dimethyl-6-(5-methyl-furan-2-yl)-11-phenyl-6,7...)
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of CFTR in nonpermeabilized human T84 cells assessed as inhibition of forskolin and IBMX-induced chloride current by short-circuit current...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50324734(7,9-Dimethyl-6-(5-methyl-furan-2-yl)-11-phenyl-6,7...)
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of CFTR in nonpermeabilized human bronchial epithelial cells assessed as inhibition of forskolin and IBMX-induced chloride current at by s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed