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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
4
hits in this display
Target
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50303035
(4-(4-(5-methylthiophen-2-yl)pyrimidin-2-ylamino)be...)
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Affinity Data
IC50: 19nM
Assay Description:
Inhibition of FLAG-tagged IKKbeta after 30 mins
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50303035
(4-(4-(5-methylthiophen-2-yl)pyrimidin-2-ylamino)be...)
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Affinity Data
IC50: 200nM
Assay Description:
Inhibition of GSK3beta
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50303035
(4-(4-(5-methylthiophen-2-yl)pyrimidin-2-ylamino)be...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.71E+3nM
Assay Description:
Inhibition of IKKbeta expressed in human HeLa cells transfected with pNFkappaB-luciferase assessed inhibition of TNFalpha-induced NF-kappaB expressio...
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Dickkopf-related protein 1
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50303035
(4-(4-(5-methylthiophen-2-yl)pyrimidin-2-ylamino)be...)
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Copy InChI
Affinity Data
EC50: 7.80E+3nM
Assay Description:
Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase response
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI