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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
8
hits in this display
Target
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human))
Galapagos
Curated by
ChEMBL
Ligand
BDBM379553
(US9926281, Compound 27)
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Affinity Data
IC50: 84nM
Assay Description:
Inhibition of human recombinant ADAMTS-5 assessed as cleavage of fluorescent substrate using FAM-TBIS-1 by biochemical assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
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Target
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human))
Galapagos
Curated by
ChEMBL
Ligand
BDBM379553
(US9926281, Compound 27)
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Affinity Data
IC50: 90nM
Assay Description:
ADAMTS-5:Protocol 1: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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Target
ADAMTS5
(Rattus norvegicus (Rat))
Galapagos
US Patent
Ligand
BDBM379553
(US9926281, Compound 27)
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Affinity Data
IC50: 124nM
Assay Description:
ADAMTS-4:The basis for the assay is the cleavage of the substrate TBIS-1 (5-FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMTS4For the do...
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Target Info
PDB
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
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PC sid
In Depth
Details
US Patent
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Target
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human))
Galapagos
US Patent
Ligand
BDBM379553
(US9926281, Compound 27)
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Affinity Data
IC50: >2.00E+3nM
Assay Description:
TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...
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Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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Target
72 kDa type IV collagenase
(Homo sapiens (Human))
Galapagos
US Patent
Ligand
BDBM379553
(US9926281, Compound 27)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
MMP2: Protocol 1: The basis for the assay is the cleavage of the substrate 520 MMP fret substrate XV (Anaspec, Catalog #: AS-60582-01) by human MMP2 ...
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Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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Target
Collagenase 3
(Homo sapiens (Human))
Galapagos
US Patent
Ligand
BDBM379553
(US9926281, Compound 27)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
MMP-13:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat # AS-27076) by human MMP13 (Chemicon, Cat #CC06...
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Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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Target
Matrix metalloproteinase-14
(Homo sapiens (Human))
Galapagos
US Patent
Ligand
BDBM379553
(US9926281, Compound 27)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
MMP-14:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat # AS-27076) by human MMP14 (Biomol, Cat #SE-259...
More data for this Ligand-Target Pair
Target Info
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antibodypedia
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Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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Target
Interstitial collagenase
(Homo sapiens (Human))
Galapagos
US Patent
Ligand
BDBM379553
(US9926281, Compound 27)
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Affinity Data
IC50: 3.00E+4nM
Assay Description:
Inhibition of the proteases human MMP1 was determined at REACTION BIOLOGY (Reaction Biology Corp. 1 Great Valley Parkway, Suite 2 Malvern, Pa. 19355,...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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