Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetProtein Wnt-2(Mus musculus (Mouse))
University of Texas Southwestern Medical Center

LigandBDBM36412(CID25093486 | N-(4-Methylquinolin-8-yl)-4-(endo-4-...)Copy SMILESCopy InChI

Affinity DataIC50:  27nMpH: 7.4 T: 2°CAssay Description:Inhibition assay of Wnt response treated with exogenously supplied of Wnt protein ('exogenous Wnt' test)More data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Amgen

Curated by ChEMBL

LigandBDBM50425970(CHEMBL1257010)Copy SMILESCopy InChI

Affinity DataIC50:  36nMAssay Description:Inhibition of N-terminal His6-tagged human TNKS2 (946 to 1162 amino acid residues) after 60 mins by autoparsylation assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Amgen

Curated by ChEMBL

LigandBDBM50425970(CHEMBL1257010)Copy SMILESCopy InChI

Affinity DataIC50:  192nMAssay Description:Inhibition of N-terminal His6-tagged human TNKS1 (1091 to 1325 amino acid residues) after 60 mins by autoparsylation assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI