Home
About
Info
Download
WebServices
Contact
Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
40
hits in this display
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 5.30nM
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 5.40nM
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 12nM
Assay Description:
Displacement by compound of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranes
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 14.1nM
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 16nM
Assay Description:
Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 16nM
Assay Description:
Displacement of [3HMPEP from rat cloned mGluR5 expressed in HEK293T cells by by scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 16nM
Assay Description:
Displacement of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from mGlu5R in rat cortical membranes by liquid scintillation spectrometric analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 16nM
Assay Description:
Tested for displacement of [3H]3-methoxy-5-(pyridin-2-ylethynyl) pyridine from Metabotropic glutamate receptor 5 in rat cortical membrane
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 17.8nM
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 33nM
Assay Description:
Displacement of [3H]MPEP from human cloned mGluR5 receptor expressed in CHO-T-Rex cells after 60 mins by liquid scintillation spectrometry
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 33nM
Assay Description:
Displacement of [3H]MPEP from human mGlu5 receptor expressed in CHO-TREx cell membranes after 60 mins by liquid scintillation spectrometric analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 33nM
Assay Description:
Displacement of [3H]MPEP from human mGlu5 receptor expressed in CHO-TREx cell membranes after 60 mins by liquid scintillation spectrometric analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 39nM
Assay Description:
Displacement of [3H]MPEP from mGluR5 receptor in Sprague-Dawley rat forebrain membrane after 60 mins by liquid scintillation spectrometry
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 42nM
Assay Description:
Displacement of [3H]MPEP from mGluR5 in Sprague-Dawley rat brain membrane after 60 mins by liquid scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 1A2
(Homo sapiens (Human))
Recordati
Curated by
ChEMBL
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 500nM
Assay Description:
Competitive inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 20 mins by LC-MS/MS analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 1A2
(Homo sapiens (Human))
Recordati
Curated by
ChEMBL
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 500nM
Assay Description:
Competitive inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 20 mins by LC-MS/MS analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 1
(RAT)
Recordati
Curated by
ChEMBL
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
Assay Description:
Displacement of [3H]MPEP from rat mGlu1 receptor expressed in CHO-TREx cell membranes after 30 mins by liquid scintillation spectrometric analysis
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 1
(RAT)
Recordati
Curated by
ChEMBL
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
Assay Description:
Displacement of [3H]MPEP from rat mGlu1 receptor expressed in CHO-TREx cell membranes after 30 mins by liquid scintillation spectrometric analysis
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 1
(RAT)
Recordati
Curated by
ChEMBL
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
Assay Description:
Displacement of [3H]R214127 from rat cloned mGluR1 receptor expressed in CHO-T-Rex cells after 30 mins by liquid scintillation spectrometry
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5nM
Assay Description:
Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5nM
Assay Description:
Tested in vitro against human recombinant Metabotropic glutamate receptor 5 stably expressed in LtK cells by [Ca2+] flux assay using glutamate as ant...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5nM
Assay Description:
Inhibitory concentration against human recombinant metabotropic glutamate receptor 5 (mGlu5) in Ltk cells determined using fluorescence detection met...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5nM
Assay Description:
In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonist
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5nM
Assay Description:
In vitro functional potency using an automated assay employing LtK-cells stably expressing human recombinant mGlu5 receptor by measuring changes in c...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 12nM
Assay Description:
Negative allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 14nM
Assay Description:
Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 47nM
Assay Description:
Negative allosteric modulatory activity at human cloned mGluR5 receptor expressed in CHO-T-Rex cells assessed as inhibiton of quisqualate-induced cal...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 47nM
Assay Description:
Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 47nM
Assay Description:
Negative allosteric modulation of human mGlu5 receptor expressed in CHO-TREx cell membranes assessed as reduction in quisqualate-induced Ca2+ mobiliz...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 77nM
Assay Description:
Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPR
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 110nM
Assay Description:
Inverse agonist activity at rat mGluR5 expressed in HEK293A cells coexpressing Gqalpha assessed as inhibition of quisqualic-induced D-myo-inositol 1 ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 462nM
Assay Description:
Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5a
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
PDSP K
i
Database
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 462nM
Assay Description:
Antagonist activity against mGluR5 expressed in CHO cells assessed as inhibition of agonist-induced phosphoinositide hydrolysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Amine oxidase [flavin-containing] A
(Mus musculus)
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.00E+4nM
Assay Description:
Tested for in vitro antagonistic activity against Monoamine oxidase A
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Recordati
Curated by
ChEMBL
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 6.07E+4nM
Assay Description:
Inhibition of recombinant human CYP2D6 using 3-[2-(N,N-diethylamino)ethyl]-7-methoxy-4-methylcoumarin as substrate preincubated for 10 mins followed ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Recordati
Curated by
ChEMBL
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 6.07E+4nM
Assay Description:
Inhibition of recombinant human CYP2D6 using 3-[2-(N,N-diethylamino)ethyl]-7-methoxy-4-methylcoumarin as substrate preincubated for 10 mins followed ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Recordati
Curated by
ChEMBL
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of recombinant human CYP3A4 using 7-benzyloxy-trifluoromethylcoumarin as substrate preincubated for 10 mins followed by substrate addition...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Recordati
Curated by
ChEMBL
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of recombinant human CYP3A4 using 7-benzyloxy-trifluoromethylcoumarin as substrate preincubated for 10 mins followed by substrate addition...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 1
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
Tested for in vitro antagonistic activity against Metabotropic glutamate receptor 1
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Glutamate receptor ionotropic, NMDA 2B
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50122758
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >3.00E+5nM
Assay Description:
Tested for in vitro antagonistic activity against recombinat human N-methyl-D-aspartate glutamate receptor 2B
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI