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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 7 hits in this display   

TargetNeutrophil collagenase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26791(benzimidazole analog., 17 | tert-butyl (3S,4S)-3-(...)
Affinity DataKi:  1.87E+3nM ΔG°:  -32.7kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26791(benzimidazole analog., 17 | tert-butyl (3S,4S)-3-(...)
Affinity DataKi:  2.61E+3nM ΔG°:  -31.9kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26791(benzimidazole analog., 17 | tert-butyl (3S,4S)-3-(...)
Affinity DataKi: >5.03E+3nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26791(benzimidazole analog., 17 | tert-butyl (3S,4S)-3-(...)
Affinity DataKi:  5.86E+3nM ΔG°:  -29.9kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
Bristol-Myers Squibb

LigandPNGBDBM26791(benzimidazole analog., 17 | tert-butyl (3S,4S)-3-(...)
Affinity DataIC50:  1nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26791(benzimidazole analog., 17 | tert-butyl (3S,4S)-3-(...)
Affinity DataIC50:  250nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-2(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26791(benzimidazole analog., 17 | tert-butyl (3S,4S)-3-(...)
Affinity DataIC50:  1.60E+3nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed