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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 10 hits in this display   

TargetMenin(Homo sapiens (Human))
University of Michigan

US Patent
LigandPNGBDBM152260(US8993552, 1F4 Compound 44)
Affinity DataIC50:  3.80E+5nMAssay Description:Assays effective in monitoring the inhibition of the MLL binding to menin were developed during experiments performed during the development of embod...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM152260(US8993552, 1F4 Compound 44)
Affinity DataKd:  2.50E+5nMAssay Description:Binding affinity to human His6-tagged PCAF expressed in Escherichia coli BL21(DE3)-R3 using methanol by SPR assayMore data for this Ligand-Target Pair
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM152260(US8993552, 1F4 Compound 44)
Affinity DataKd:  6.60E+5nMAssay Description:Binding affinity to human His6-tagged PCAF expressed in Escherichia coli BL21(DE3)-R3 using 1% DMSO by SPR assayMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM152260(US8993552, 1F4 Compound 44)
Affinity DataKd:  1.01E+5nMAssay Description:Binding affinity to human wild type adenosine A3 receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM152260(US8993552, 1F4 Compound 44)
Affinity DataKd:  2.50E+5nMAssay Description:Displacement of biotinylated small molecule ligand from His/FLAG-tagged PCAF bromodomain (719 to 832 residues) (unknown origin) after 15 mins by Alph...More data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM152260(US8993552, 1F4 Compound 44)
Affinity DataKd:  4.10E+5nMAssay Description:Binding affinity to human wild type adenosine A2A receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM152260(US8993552, 1F4 Compound 44)
Affinity DataKd:  7.80E+4nMAssay Description:Binding affinity to human wild type adenosine A1 receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM152260(US8993552, 1F4 Compound 44)
Affinity DataKd:  1.40E+5nMAssay Description:Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM152260(US8993552, 1F4 Compound 44)
Affinity DataKd:  1.08E+6nMAssay Description:Binding affinity to human His6-tagged PCAF expressed in Escherichia coli BL21(DE3)-R3 using 3% DMSO by SPR assayMore data for this Ligand-Target Pair
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM152260(US8993552, 1F4 Compound 44)
Affinity DataKd:  3.60E+5nMAssay Description:Binding affinity to human His6-tagged PCAF expressed in Escherichia coli BL21(DE3)-R3 using 0.5% DMSO by SPR assayMore data for this Ligand-Target Pair