Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 19 hits in this display   

TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Merck Frosst Canada

US Patent
LigandPNGBDBM50308131(4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]...)
Affinity DataKi:  0.5nM ΔG°:  -53.1kJ/molepH: 6.0 T: 2°CAssay Description:Transfected HEK 293(ebna) cells are maintained in culture, harvested and membranes are prepared by differential centrifugation, following lysis of th...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Merck Frosst Canada

US Patent
LigandPNGBDBM50308131(4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]...)
Affinity DataKi:  0.560nMAssay Description:Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Rattus norvegicus)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308131(4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]PGE2 from rat EP4 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Merck Frosst Canada

US Patent
LigandPNGBDBM50308131(4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]...)
Affinity DataKi:  0.970nMAssay Description:Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293-EBNA cells by scintillation counting in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(RAT)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308131(4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]...)
Affinity DataKi:  3.30E+3nMAssay Description:Displacement of [3H]PGE2 from rat EP3 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308131(4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]...)
Affinity DataKi: >3.90E+3nMAssay Description:Displacement of [3H]PGD2 from human DP1 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308131(4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]...)
Affinity DataKi: >5.60E+3nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308131(4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]...)
Affinity DataKi:  5.90E+3nMAssay Description:Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308131(4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]...)
Affinity DataKi: >6.80E+3nMAssay Description:Displacement of [3H]SQ29548 from human TP receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Rattus norvegicus)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308131(4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]...)
Affinity DataKi:  7.20E+3nMAssay Description:Displacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308131(4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]...)
Affinity DataKi: >7.90E+3nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308131(4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]...)
Affinity DataKi: >2.10E+4nMAssay Description:Displacement of [3H]PGD2 from human DP2 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308131(4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]...)
Affinity DataKi: >2.20E+4nMAssay Description:Displacement of [3H]iloprost from human IP receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin F2-alpha receptor(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308131(4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]...)
Affinity DataKi: >2.40E+4nMAssay Description:Displacement of [3H]PGF2alpha from human FP receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50308131(4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]...)
Affinity DataKi: >2.90E+4nMAssay Description:Displacement of [3H]PGE2 from rat EP1 receptor expressed in HEK293-EBNA cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Merck Frosst Canada

US Patent
LigandPNGBDBM50308131(4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]...)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Merck Frosst Canada

US Patent
LigandPNGBDBM50308131(4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]...)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity at human EP4 receptor transfected in CHO/Galpha16 cells preincubated for 15 mins followed by PGE2 addition by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Merck Frosst Canada

US Patent
LigandPNGBDBM50308131(4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]...)
Affinity DataIC50:  2.90nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Merck Frosst Canada

US Patent
LigandPNGBDBM50308131(4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]...)
Affinity DataIC50:  11nMAssay Description:Activity at EP4 receptor in human whole blood assessed as blockade of inhibition of TNFalpha-induced IP10 releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed